Integrated Approach Reveals Role of Mitochondrial Germ-Line Mutation F18L in Respiratory Chain, Oxidative Alterations, Drug Sensitivity, and Patient Prognosis in Glioblastoma

Glioblastoma is the most common and malignant primary brain tumour in adults, with a dismal prognosis. This is partly due to considerable inter- and intra-tumour heterogeneity. Changes in the cellular energy-producing mitochondrial respiratory chain complex (MRC) activities are a hallmark of gliobla...

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Detalles Bibliográficos
Autores principales: Keatley, Kathleen, Stromei-Cleroux, Samuel, Wiltshire, Tammy, Rajala, Nina, Burton, Gary, Holt, William V., Littlewood, D. Timothy J., Briscoe, Andrew G., Jung, Josephine, Ashkan, Keyoumars, Heales, Simon J., Pilkington, Geoffrey J., Meunier, Brigitte, McGeehan, John E., Hargreaves, Iain P., McGeehan, Rhiannon E.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6651022/
https://www.ncbi.nlm.nih.gov/pubmed/31323957
http://dx.doi.org/10.3390/ijms20133364

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