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Development and Bone Regeneration Capacity of Premixed Magnesium Phosphate Cement Pastes
Magnesium phosphate cements (MPC) have been demonstrated to have a superior bone regeneration capacity due to their good solubility under in vivo conditions. While in the past only aqueous MPC pastes have been applied, the current study describes the fabrication and in vitro/in vivo testing of an oi...
Autores principales: | , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2019
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6651064/ https://www.ncbi.nlm.nih.gov/pubmed/31266228 http://dx.doi.org/10.3390/ma12132119 |
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author | Ewald, Andrea Kreczy, Dorothea Brückner, Theresa Gbureck, Uwe Bengel, Melanie Hoess, Andreas Nies, Berthold Bator, Julia Klammert, Uwe Fuchs, Andreas |
author_facet | Ewald, Andrea Kreczy, Dorothea Brückner, Theresa Gbureck, Uwe Bengel, Melanie Hoess, Andreas Nies, Berthold Bator, Julia Klammert, Uwe Fuchs, Andreas |
author_sort | Ewald, Andrea |
collection | PubMed |
description | Magnesium phosphate cements (MPC) have been demonstrated to have a superior bone regeneration capacity due to their good solubility under in vivo conditions. While in the past only aqueous MPC pastes have been applied, the current study describes the fabrication and in vitro/in vivo testing of an oil-based calcium doped magnesium phosphate (CaMgP) cement paste. Premixed oil-based pastes with CaMgP chemistry combine the advantages of conventional MPC such as high mechanical strength and good resorbability with a prolonged shelf-life and an easier clinical handling. The pastes set in an aqueous environment and predominantly form struvite and achieve a compressive strength of ~8–10 MPa after setting. The implantation into a drill-hole defect at the distal femoral condyle of New Zealand white rabbits over a course of 6 and 12 weeks demonstrated good biocompatibility of the materials without the formation of soft connective tissue or any signs of inflammation. In contrast to a hydroxyapatite forming reference paste, the premixed CaMgP pastes showed subsequent degradation and bony regeneration. The CaMgP cement pastes presented herein are promising bone replacement materials with excellent material properties for an improved and facilitated clinical application. |
format | Online Article Text |
id | pubmed-6651064 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2019 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-66510642019-08-07 Development and Bone Regeneration Capacity of Premixed Magnesium Phosphate Cement Pastes Ewald, Andrea Kreczy, Dorothea Brückner, Theresa Gbureck, Uwe Bengel, Melanie Hoess, Andreas Nies, Berthold Bator, Julia Klammert, Uwe Fuchs, Andreas Materials (Basel) Article Magnesium phosphate cements (MPC) have been demonstrated to have a superior bone regeneration capacity due to their good solubility under in vivo conditions. While in the past only aqueous MPC pastes have been applied, the current study describes the fabrication and in vitro/in vivo testing of an oil-based calcium doped magnesium phosphate (CaMgP) cement paste. Premixed oil-based pastes with CaMgP chemistry combine the advantages of conventional MPC such as high mechanical strength and good resorbability with a prolonged shelf-life and an easier clinical handling. The pastes set in an aqueous environment and predominantly form struvite and achieve a compressive strength of ~8–10 MPa after setting. The implantation into a drill-hole defect at the distal femoral condyle of New Zealand white rabbits over a course of 6 and 12 weeks demonstrated good biocompatibility of the materials without the formation of soft connective tissue or any signs of inflammation. In contrast to a hydroxyapatite forming reference paste, the premixed CaMgP pastes showed subsequent degradation and bony regeneration. The CaMgP cement pastes presented herein are promising bone replacement materials with excellent material properties for an improved and facilitated clinical application. MDPI 2019-07-01 /pmc/articles/PMC6651064/ /pubmed/31266228 http://dx.doi.org/10.3390/ma12132119 Text en © 2019 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Ewald, Andrea Kreczy, Dorothea Brückner, Theresa Gbureck, Uwe Bengel, Melanie Hoess, Andreas Nies, Berthold Bator, Julia Klammert, Uwe Fuchs, Andreas Development and Bone Regeneration Capacity of Premixed Magnesium Phosphate Cement Pastes |
title | Development and Bone Regeneration Capacity of Premixed Magnesium Phosphate Cement Pastes |
title_full | Development and Bone Regeneration Capacity of Premixed Magnesium Phosphate Cement Pastes |
title_fullStr | Development and Bone Regeneration Capacity of Premixed Magnesium Phosphate Cement Pastes |
title_full_unstemmed | Development and Bone Regeneration Capacity of Premixed Magnesium Phosphate Cement Pastes |
title_short | Development and Bone Regeneration Capacity of Premixed Magnesium Phosphate Cement Pastes |
title_sort | development and bone regeneration capacity of premixed magnesium phosphate cement pastes |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6651064/ https://www.ncbi.nlm.nih.gov/pubmed/31266228 http://dx.doi.org/10.3390/ma12132119 |
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