In Situ Oxidation of Cu(2)O Crystal for Electrochemical Detection of Glucose

The development of a sensitive, quick-responding, and robust glucose sensor is consistently pursued for use in numerous applications. Here, we propose a new method for preparing a Cu(2)O electrode for the electrochemical detection of glucose concentration. The Cu(2)O glucose electrode was prepared by in situ electrical oxidation in an alkaline solution, in which Cu(2)O nanoparticles were deposited on the electrode surface to form a thin film, followed by the growth of Cu(OH)(2) nanorods or nanotubes. The morphology and electrocatalytic activity of a Cu(2)O glucose electrode can be tuned by the current density, reaction time, and NaOH concentration. The results from XRD, SEM, and a Raman spectrum show that the electrode surface was coated with cubic Cu(2)O nanoparticles with diameters ranging from 50 to 150 nm. The electrode exhibited a detection limit of 0.0275 mM, a peak sensitivity of 2524.9 μA·cm(−2)·mM(−1), and a linear response range from 0.1 to 1 mM. The presence of high concentrations of ascorbic acid, uric acid, dopamine and lactose appeared to have no effects on the detection of glucose, indicating a high specificity and robustness of this electrode.