Marylosides A-G, Norcycloartane Glycosides from Leaves of Cymbidium Great Flower ‘Marylaurencin’

Seven novel norcycloartane glycosides, maryloside A–G (1–7), were isolated from the leaves of Cymbidium Great Flower ‘Marylaurencin’, along with a known norcycloartane glycoside, cymbidoside (8). These structures were determined on the basis of mainly NMR experiments as well as chemical degradation...

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Detalles Bibliográficos
Autores principales: Yoneyama, Tatsuro, Iseki, Kanako, Noji, Masaaki, Imagawa, Hiroshi, Hashimoto, Toshihiro, Kawano, Sachiko, Baba, Masaki, Kashiwada, Yoshiki, Yahagi, Tadahiro, Matsuzaki, Keiichi, Umeyama, Akemi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6651146/
https://www.ncbi.nlm.nih.gov/pubmed/31323985
http://dx.doi.org/10.3390/molecules24132504
Descripción
Sumario:Seven novel norcycloartane glycosides, maryloside A–G (1–7), were isolated from the leaves of Cymbidium Great Flower ‘Marylaurencin’, along with a known norcycloartane glycoside, cymbidoside (8). These structures were determined on the basis of mainly NMR experiments as well as chemical degradation and X-ray crystallographic analysis. The isolated compounds (1–6 and 8) were evaluated for the inhibitory activity on lipopolysaccharide (LPS) and interferon-γ (IFN-γ)-stimulated nitric oxide (NO) production in RAW 264.7 cells. Consequently, 1 and 3 exhibited moderate activity.

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