The 3S Enantiomer Drives Enolase Inhibitory Activity in SF2312 and Its Analogues

We recently reported that SF2312 ((1,5-dihydroxy-2-oxopyrrolidin-3-yl)phosphonic acid), a phosphonate antibiotic with a previously unknown mode of action, is a potent inhibitor of the glycolytic enzyme, Enolase. SF2312 can only be synthesized as a racemic-diastereomeric mixture. However, co-crystal...

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Detalles Bibliográficos
Autores principales: Pisaneschi, Federica, Lin, Yu-Hsi, Leonard, Paul G., Satani, Nikunj, Yan, Victoria C., Hammoudi, Naima, Raghavan, Sudhir, Link, Todd M., K. Georgiou, Dimitra, Czako, Barbara, Muller, Florian L.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6651268/
https://www.ncbi.nlm.nih.gov/pubmed/31324042
http://dx.doi.org/10.3390/molecules24132510

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