The Formation and Therapeutic Update of Tumor-Associated Macrophages in Cervical Cancer

Both clinicopathological and experimental studies have suggested that tumor-associated macrophages (TAMs) play a key role in cervical cancer progression and are associated with poor prognosis in the respects of tumor cell proliferation, invasion, angiogenesis, and immunosuppression. Therefore, havin...

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Detalles Bibliográficos
Autores principales: Wang, Qun, Steger, Alexander, Mahner, Sven, Jeschke, Udo, Heidegger, Helene
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2019
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6651300/
https://www.ncbi.nlm.nih.gov/pubmed/31284453
http://dx.doi.org/10.3390/ijms20133310
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author Wang, Qun
Steger, Alexander
Mahner, Sven
Jeschke, Udo
Heidegger, Helene
author_facet Wang, Qun
Steger, Alexander
Mahner, Sven
Jeschke, Udo
Heidegger, Helene
author_sort Wang, Qun
collection PubMed
description Both clinicopathological and experimental studies have suggested that tumor-associated macrophages (TAMs) play a key role in cervical cancer progression and are associated with poor prognosis in the respects of tumor cell proliferation, invasion, angiogenesis, and immunosuppression. Therefore, having a clear understanding of TAMs is essential in treating this disease. In this review, we will discuss the origins and categories of macrophages, the molecules responsible for forming and reeducating TAMs in cervical cancer (CC), the biomarkers of macrophages and the therapy development targeting TAMs in CC research.
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spelling pubmed-66513002019-08-08 The Formation and Therapeutic Update of Tumor-Associated Macrophages in Cervical Cancer Wang, Qun Steger, Alexander Mahner, Sven Jeschke, Udo Heidegger, Helene Int J Mol Sci Review Both clinicopathological and experimental studies have suggested that tumor-associated macrophages (TAMs) play a key role in cervical cancer progression and are associated with poor prognosis in the respects of tumor cell proliferation, invasion, angiogenesis, and immunosuppression. Therefore, having a clear understanding of TAMs is essential in treating this disease. In this review, we will discuss the origins and categories of macrophages, the molecules responsible for forming and reeducating TAMs in cervical cancer (CC), the biomarkers of macrophages and the therapy development targeting TAMs in CC research. MDPI 2019-07-05 /pmc/articles/PMC6651300/ /pubmed/31284453 http://dx.doi.org/10.3390/ijms20133310 Text en © 2019 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Wang, Qun
Steger, Alexander
Mahner, Sven
Jeschke, Udo
Heidegger, Helene
The Formation and Therapeutic Update of Tumor-Associated Macrophages in Cervical Cancer
title The Formation and Therapeutic Update of Tumor-Associated Macrophages in Cervical Cancer
title_full The Formation and Therapeutic Update of Tumor-Associated Macrophages in Cervical Cancer
title_fullStr The Formation and Therapeutic Update of Tumor-Associated Macrophages in Cervical Cancer
title_full_unstemmed The Formation and Therapeutic Update of Tumor-Associated Macrophages in Cervical Cancer
title_short The Formation and Therapeutic Update of Tumor-Associated Macrophages in Cervical Cancer
title_sort formation and therapeutic update of tumor-associated macrophages in cervical cancer
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6651300/
https://www.ncbi.nlm.nih.gov/pubmed/31284453
http://dx.doi.org/10.3390/ijms20133310
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