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Telmisartan Inhibits Cell Proliferation and Tumor Growth of Esophageal Squamous Cell Carcinoma by Inducing S-Phase Arrest In Vitro and In Vivo

Esophageal squamous cell carcinoma (ESCC) is the most common primary esophageal malignancy. Telmisartan, an angiotensin II type 1 (AT1) receptor blocker (ARB) and a widely used antihypertensive, has been shown to inhibit proliferation of various cancer types. This study evaluated the effects of telm...

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Autores principales: Matsui, Takanori, Chiyo, Taiga, Kobara, Hideki, Fujihara, Shintaro, Fujita, Koji, Namima, Daisuke, Nakahara, Mai, Kobayashi, Nobuya, Nishiyama, Noriko, Yachida, Tatsuo, Morishita, Asahiro, Iwama, Hisakazu, Masaki, Tsutomu
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6651359/
https://www.ncbi.nlm.nih.gov/pubmed/31261874
http://dx.doi.org/10.3390/ijms20133197
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author Matsui, Takanori
Chiyo, Taiga
Kobara, Hideki
Fujihara, Shintaro
Fujita, Koji
Namima, Daisuke
Nakahara, Mai
Kobayashi, Nobuya
Nishiyama, Noriko
Yachida, Tatsuo
Morishita, Asahiro
Iwama, Hisakazu
Masaki, Tsutomu
author_facet Matsui, Takanori
Chiyo, Taiga
Kobara, Hideki
Fujihara, Shintaro
Fujita, Koji
Namima, Daisuke
Nakahara, Mai
Kobayashi, Nobuya
Nishiyama, Noriko
Yachida, Tatsuo
Morishita, Asahiro
Iwama, Hisakazu
Masaki, Tsutomu
author_sort Matsui, Takanori
collection PubMed
description Esophageal squamous cell carcinoma (ESCC) is the most common primary esophageal malignancy. Telmisartan, an angiotensin II type 1 (AT1) receptor blocker (ARB) and a widely used antihypertensive, has been shown to inhibit proliferation of various cancer types. This study evaluated the effects of telmisartan on human ESCC cell proliferation in vitro and in vivo and sought to identify the microRNAs (miRNAs) involved in these antitumor effects. We examined the effects of telmisartan on three human ESCC cell lines (KYSE150, KYSE180, and KYSE850). Telmisartan inhibited proliferation of these three cell lines by inducing S-phase arrest, which was accompanied by decreased expression of cyclin A2, cyclin-dependent kinase 2, and other cell cycle-related proteins. Additionally, telmisartan reduced levels of phosphorylated ErbB3 and thrombospondin-1 in KYSE180 cells. Furthermore, expression of miRNAs was remarkably altered by telmisartan in vitro. Telmisartan also inhibited tumor growth in vivo in a xenograft mouse model. In conclusion, telmisartan inhibited cell proliferation and tumor growth in ESCC cells by inducing cell-cycle arrest.
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spelling pubmed-66513592019-08-08 Telmisartan Inhibits Cell Proliferation and Tumor Growth of Esophageal Squamous Cell Carcinoma by Inducing S-Phase Arrest In Vitro and In Vivo Matsui, Takanori Chiyo, Taiga Kobara, Hideki Fujihara, Shintaro Fujita, Koji Namima, Daisuke Nakahara, Mai Kobayashi, Nobuya Nishiyama, Noriko Yachida, Tatsuo Morishita, Asahiro Iwama, Hisakazu Masaki, Tsutomu Int J Mol Sci Article Esophageal squamous cell carcinoma (ESCC) is the most common primary esophageal malignancy. Telmisartan, an angiotensin II type 1 (AT1) receptor blocker (ARB) and a widely used antihypertensive, has been shown to inhibit proliferation of various cancer types. This study evaluated the effects of telmisartan on human ESCC cell proliferation in vitro and in vivo and sought to identify the microRNAs (miRNAs) involved in these antitumor effects. We examined the effects of telmisartan on three human ESCC cell lines (KYSE150, KYSE180, and KYSE850). Telmisartan inhibited proliferation of these three cell lines by inducing S-phase arrest, which was accompanied by decreased expression of cyclin A2, cyclin-dependent kinase 2, and other cell cycle-related proteins. Additionally, telmisartan reduced levels of phosphorylated ErbB3 and thrombospondin-1 in KYSE180 cells. Furthermore, expression of miRNAs was remarkably altered by telmisartan in vitro. Telmisartan also inhibited tumor growth in vivo in a xenograft mouse model. In conclusion, telmisartan inhibited cell proliferation and tumor growth in ESCC cells by inducing cell-cycle arrest. MDPI 2019-06-29 /pmc/articles/PMC6651359/ /pubmed/31261874 http://dx.doi.org/10.3390/ijms20133197 Text en © 2019 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Matsui, Takanori
Chiyo, Taiga
Kobara, Hideki
Fujihara, Shintaro
Fujita, Koji
Namima, Daisuke
Nakahara, Mai
Kobayashi, Nobuya
Nishiyama, Noriko
Yachida, Tatsuo
Morishita, Asahiro
Iwama, Hisakazu
Masaki, Tsutomu
Telmisartan Inhibits Cell Proliferation and Tumor Growth of Esophageal Squamous Cell Carcinoma by Inducing S-Phase Arrest In Vitro and In Vivo
title Telmisartan Inhibits Cell Proliferation and Tumor Growth of Esophageal Squamous Cell Carcinoma by Inducing S-Phase Arrest In Vitro and In Vivo
title_full Telmisartan Inhibits Cell Proliferation and Tumor Growth of Esophageal Squamous Cell Carcinoma by Inducing S-Phase Arrest In Vitro and In Vivo
title_fullStr Telmisartan Inhibits Cell Proliferation and Tumor Growth of Esophageal Squamous Cell Carcinoma by Inducing S-Phase Arrest In Vitro and In Vivo
title_full_unstemmed Telmisartan Inhibits Cell Proliferation and Tumor Growth of Esophageal Squamous Cell Carcinoma by Inducing S-Phase Arrest In Vitro and In Vivo
title_short Telmisartan Inhibits Cell Proliferation and Tumor Growth of Esophageal Squamous Cell Carcinoma by Inducing S-Phase Arrest In Vitro and In Vivo
title_sort telmisartan inhibits cell proliferation and tumor growth of esophageal squamous cell carcinoma by inducing s-phase arrest in vitro and in vivo
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6651359/
https://www.ncbi.nlm.nih.gov/pubmed/31261874
http://dx.doi.org/10.3390/ijms20133197
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