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Telmisartan Inhibits Cell Proliferation and Tumor Growth of Esophageal Squamous Cell Carcinoma by Inducing S-Phase Arrest In Vitro and In Vivo
Esophageal squamous cell carcinoma (ESCC) is the most common primary esophageal malignancy. Telmisartan, an angiotensin II type 1 (AT1) receptor blocker (ARB) and a widely used antihypertensive, has been shown to inhibit proliferation of various cancer types. This study evaluated the effects of telm...
Autores principales: | , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2019
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6651359/ https://www.ncbi.nlm.nih.gov/pubmed/31261874 http://dx.doi.org/10.3390/ijms20133197 |
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author | Matsui, Takanori Chiyo, Taiga Kobara, Hideki Fujihara, Shintaro Fujita, Koji Namima, Daisuke Nakahara, Mai Kobayashi, Nobuya Nishiyama, Noriko Yachida, Tatsuo Morishita, Asahiro Iwama, Hisakazu Masaki, Tsutomu |
author_facet | Matsui, Takanori Chiyo, Taiga Kobara, Hideki Fujihara, Shintaro Fujita, Koji Namima, Daisuke Nakahara, Mai Kobayashi, Nobuya Nishiyama, Noriko Yachida, Tatsuo Morishita, Asahiro Iwama, Hisakazu Masaki, Tsutomu |
author_sort | Matsui, Takanori |
collection | PubMed |
description | Esophageal squamous cell carcinoma (ESCC) is the most common primary esophageal malignancy. Telmisartan, an angiotensin II type 1 (AT1) receptor blocker (ARB) and a widely used antihypertensive, has been shown to inhibit proliferation of various cancer types. This study evaluated the effects of telmisartan on human ESCC cell proliferation in vitro and in vivo and sought to identify the microRNAs (miRNAs) involved in these antitumor effects. We examined the effects of telmisartan on three human ESCC cell lines (KYSE150, KYSE180, and KYSE850). Telmisartan inhibited proliferation of these three cell lines by inducing S-phase arrest, which was accompanied by decreased expression of cyclin A2, cyclin-dependent kinase 2, and other cell cycle-related proteins. Additionally, telmisartan reduced levels of phosphorylated ErbB3 and thrombospondin-1 in KYSE180 cells. Furthermore, expression of miRNAs was remarkably altered by telmisartan in vitro. Telmisartan also inhibited tumor growth in vivo in a xenograft mouse model. In conclusion, telmisartan inhibited cell proliferation and tumor growth in ESCC cells by inducing cell-cycle arrest. |
format | Online Article Text |
id | pubmed-6651359 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2019 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-66513592019-08-08 Telmisartan Inhibits Cell Proliferation and Tumor Growth of Esophageal Squamous Cell Carcinoma by Inducing S-Phase Arrest In Vitro and In Vivo Matsui, Takanori Chiyo, Taiga Kobara, Hideki Fujihara, Shintaro Fujita, Koji Namima, Daisuke Nakahara, Mai Kobayashi, Nobuya Nishiyama, Noriko Yachida, Tatsuo Morishita, Asahiro Iwama, Hisakazu Masaki, Tsutomu Int J Mol Sci Article Esophageal squamous cell carcinoma (ESCC) is the most common primary esophageal malignancy. Telmisartan, an angiotensin II type 1 (AT1) receptor blocker (ARB) and a widely used antihypertensive, has been shown to inhibit proliferation of various cancer types. This study evaluated the effects of telmisartan on human ESCC cell proliferation in vitro and in vivo and sought to identify the microRNAs (miRNAs) involved in these antitumor effects. We examined the effects of telmisartan on three human ESCC cell lines (KYSE150, KYSE180, and KYSE850). Telmisartan inhibited proliferation of these three cell lines by inducing S-phase arrest, which was accompanied by decreased expression of cyclin A2, cyclin-dependent kinase 2, and other cell cycle-related proteins. Additionally, telmisartan reduced levels of phosphorylated ErbB3 and thrombospondin-1 in KYSE180 cells. Furthermore, expression of miRNAs was remarkably altered by telmisartan in vitro. Telmisartan also inhibited tumor growth in vivo in a xenograft mouse model. In conclusion, telmisartan inhibited cell proliferation and tumor growth in ESCC cells by inducing cell-cycle arrest. MDPI 2019-06-29 /pmc/articles/PMC6651359/ /pubmed/31261874 http://dx.doi.org/10.3390/ijms20133197 Text en © 2019 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Matsui, Takanori Chiyo, Taiga Kobara, Hideki Fujihara, Shintaro Fujita, Koji Namima, Daisuke Nakahara, Mai Kobayashi, Nobuya Nishiyama, Noriko Yachida, Tatsuo Morishita, Asahiro Iwama, Hisakazu Masaki, Tsutomu Telmisartan Inhibits Cell Proliferation and Tumor Growth of Esophageal Squamous Cell Carcinoma by Inducing S-Phase Arrest In Vitro and In Vivo |
title | Telmisartan Inhibits Cell Proliferation and Tumor Growth of Esophageal Squamous Cell Carcinoma by Inducing S-Phase Arrest In Vitro and In Vivo |
title_full | Telmisartan Inhibits Cell Proliferation and Tumor Growth of Esophageal Squamous Cell Carcinoma by Inducing S-Phase Arrest In Vitro and In Vivo |
title_fullStr | Telmisartan Inhibits Cell Proliferation and Tumor Growth of Esophageal Squamous Cell Carcinoma by Inducing S-Phase Arrest In Vitro and In Vivo |
title_full_unstemmed | Telmisartan Inhibits Cell Proliferation and Tumor Growth of Esophageal Squamous Cell Carcinoma by Inducing S-Phase Arrest In Vitro and In Vivo |
title_short | Telmisartan Inhibits Cell Proliferation and Tumor Growth of Esophageal Squamous Cell Carcinoma by Inducing S-Phase Arrest In Vitro and In Vivo |
title_sort | telmisartan inhibits cell proliferation and tumor growth of esophageal squamous cell carcinoma by inducing s-phase arrest in vitro and in vivo |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6651359/ https://www.ncbi.nlm.nih.gov/pubmed/31261874 http://dx.doi.org/10.3390/ijms20133197 |
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