Cargando…

Fine-Tuning the Activation Mode of an 1,3-Indandione-Based Ruthenium(II)-Cymene Half-Sandwich Complex by Variation of Its Leaving Group

Fine-tuning of the properties of a recently reported 1,3-indandione-based organoruthenium complex is attempted to optimize the stability under physiological conditions. Previous work has shown its capacity of inhibiting topoisomerase IIα; however, fast aquation leads to undesired reactions and ligan...

Descripción completa

Detalles Bibliográficos
Autores principales:	Mokesch, Stephan, Schwarz, Daniela, Hejl, Michaela, Klose, Matthias H. M., Roller, Alexander, Jakupec, Michael A., Kandioller, Wolfgang, Keppler, Bernhard K.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2019
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6651387/ https://www.ncbi.nlm.nih.gov/pubmed/31252521 http://dx.doi.org/10.3390/molecules24132373

Ejemplares similares

Physicochemical Studies and Anticancer Potency of Ruthenium η(6)-p-Cymene Complexes Containing Antibacterial Quinolones
por: Kljun, Jakob, et al.
Publicado: (2011)

Investigations on the Anticancer Potential of Benzothiazole-Based Metallacycles
por: Mokesch, Stephan, et al.
Publicado: (2020)

Half-Sandwich Rhodium Complexes with Releasable N-Donor Monodentate Ligands: Solution Chemical Properties and the Possibility for Acidosis Activation
por: Mészáros, János P., et al.
Publicado: (2023)

The First Anticancer Tris(pyrazolyl)borate Molybdenum(IV) Complexes: Tested in Vitro and in Vivo—A Comparison of O,O‐, S,O‐, and N,N‐Chelate Effects
por: Berasaluce, Iker, et al.
Publicado: (2019)

p-Cymene Complexes of Ruthenium(II) as Antitumor Agents
por: Pujante-Galián, María Angeles, et al.
Publicado: (2020)

Tridentate 3-Substituted Naphthoquinone Ruthenium Arene Complexes: Synthesis, Characterization, Aqueous Behavior, and Theoretical and Biological Studies
por: Geisler, Heiko, et al.
Publicado: (2021)

Arene Variation of Highly Cytotoxic Tridentate Naphthoquinone-Based Ruthenium(II) Complexes and In-Depth In Vitro Studies
por: Cseh, Klaudia, et al.
Publicado: (2022)

Tuning the Cytotoxicity of Bis-Phosphino-Amines Ruthenium(II) Para-Cymene Complexes for Clinical Development in Breast Cancer
por: Domínguez-Jurado, Elena, et al.
Publicado: (2021)

Anticancer Tungstenocenes with a Diverse Set of (O,O–), (O,S–) and (O,N–) Chelates—A Detailed Biological Study Using an Improved Evaluation via 3D Spheroid Models
por: Cseh, Klaudia, et al.
Publicado: (2023)

Electrochemical Study of Bromide in the Presence of 1,3-Indandione. Application to the Electrochemical Synthesis of Bromo Derivatives of 1,3-Indandione
por: Nematollahi, D., et al.
Publicado: (2001)

Synthesis, Modification, and Biological Evaluation of a Library of Novel Water‐Soluble Thiopyridone‐Based Organometallic Complexes and Their Unexpected (Biological) Behavior
por: Harringer, Sophia, et al.
Publicado: (2020)

Dichlorido(η(6)-p-cymene)(ethoxydiphenylphosphane)ruthenium(II)
por: Knapp, Spring M. M., et al.
Publicado: (2012)

Synthesis, Characterization and Biological Investigations of Half-Sandwich Ruthenium(II) Complexes Containing Benzimidazole Moiety
por: Rogala, Patrycja, et al.
Publicado: (2022)

Organometallic 3-(1H-Benzimidazol-2-yl)-1H-pyrazolo[3,4-b]pyridines as Potential Anticancer Agents
por: Stepanenko, Iryna N., et al.
Publicado: (2011)

Dichlorido(η(6)-p-cymene)(4-fluoroaniline-κN)ruthenium(II)
por: Sykora, Richard E., et al.
Publicado: (2010)

Half-Sandwich Arene Ruthenium(II) and Osmium(II) Thiosemicarbazone Complexes: Solution Behavior and Antiproliferative Activity
por: Gatti, Anna, et al.
Publicado: (2018)

Biological properties of novel ruthenium- and osmium-nitrosyl complexes with azole heterocycles
por: Novak, Maria S., et al.
Publicado: (2016)

(η(6)-p-Cymene)bis(trichloridostannyl)(triethoxyphosphine-κP)ruthenium(II)
por: Shapovalov, Sergey S., et al.
Publicado: (2009)

Two Half-Sandwiched Ruthenium (II) Compounds Containing 5-Fluorouracil Derivatives: Synthesis and Study of DNA Intercalation
por: Li, Zhao-Jun, et al.
Publicado: (2015)

Ruthenium− and Osmium−Arene Complexes of 2-Substituted Indolo[3,2-c]quinolines: Synthesis, Structure, Spectroscopic Properties, and Antiproliferative Activity
por: Filak, Lukas K., et al.
Publicado: (2010)

Carvacrol and p-cymene inactivate Escherichia coli O157:H7 in apple juice
por: Kiskó, Gabriella, et al.
Publicado: (2005)

Ligand substitutions between ruthenium–cymene compounds can control protein versus DNA targeting and anticancer activity
por: Adhireksan, Zenita, et al.
Publicado: (2014)

Facile Arene Ligand Exchange in p-Cymene Ruthenium(II) Complexes of Tertiary P-Chiral Ferrocenyl Phosphines
por: Popp, John, et al.
Publicado: (2019)

DNA-Binding Capabilities and Anticancer Activities of Ruthenium(II) Cymene Complexes with (Poly)cyclic Aromatic Diamine Ligands
por: Alsaeedi, Mona S., et al.
Publicado: (2020)

Synthesis, Characterization, and Cytotoxicity Studies of N-(4-Methoxybenzyl) Thiosemicarbazone Derivatives and Their Ruthenium(II)-p-cymene Complexes
por: Martínez-Estévez, Mónica, et al.
Publicado: (2022)

Inhibitory Effects of the Ruthenium Complex KP1019 in Models of Mammary Cancer Cell Migration and Invasion
por: Bergamo, A., et al.
Publicado: (2009)

2-Arylidene-1-indandiones as Pleiotropic Agents with Antioxidant and Inhibitory Enzymes Activities †
por: Kouzi, Olympia, et al.
Publicado: (2019)

Dichlorido(η(6)-p-cymene)[tris(4-methoxyphenyl)phosphane]ruthenium(II)
por: Davis, Wade L., et al.
Publicado: (2021)

NRF2 and Bip Interconnection Mediates Resistance to the Organometallic Ruthenium-Cymene Bisdemethoxycurcumin Complex Cytotoxicity in Colon Cancer Cells
por: Garufi, Alessia, et al.
Publicado: (2023)

Targeting Multiresistant Gram-Positive Bacteria by Ruthenium, Osmium, Iridium and Rhodium Half-Sandwich Type Complexes With Bidentate Monosaccharide Ligands
por: Balázs, Bence, et al.
Publicado: (2022)

Half-Sandwich Arene Ruthenium(II) Thiosemicarbazone Complexes: Evaluation of Anticancer Effect on Primary and Metastatic Ovarian Cancer Cell Lines
por: Guler, Seminay, et al.
Publicado: (2022)

En Route to Osmium Analogues of KP1019: Synthesis, Structure, Spectroscopic Properties and Antiproliferative Activity of trans-[Os(IV)Cl(4)(Hazole)(2)]
por: Büchel, Gabriel E., et al.
Publicado: (2011)

Combination of Drug Delivery Properties of PAMAM Dendrimers and Cytotoxicity of Platinum(IV) Complexes—A More Selective Anticancer Treatment?
por: Lerchbammer-Kreith, Yvonne, et al.
Publicado: (2023)

Biological activity of ruthenium and osmium arene complexes with modified paullones in human cancer cells
por: Mühlgassner, Gerhard, et al.
Publicado: (2012)

Crystal structure of [3-amino-2-(phenyldiazenyl)pyridine]chlorido(η(6)-p-cymene)ruthenium(II) chloride
por: Hansongnern, Kanidtha, et al.
Publicado: (2015)

A new class of half-sandwich ruthenium complexes containing Biginelli hybrids: anticancer and anti-SARS-CoV-2 activities
por: Janković, Nenad, et al.
Publicado: (2022)

Precision Covalent Chemistry for Fine-Size Tuning of Sandwiched Nanoparticles between Graphene Nanoplatelets
por: Bayazit, Mustafa K.
Publicado: (2023)

Electrochemical Synthesis of Novel 1,3-Indandione Derivatives and Evaluation of Their Antiplatelet Aggregation Activities
por: Amidi, Salimeh, et al.
Publicado: (2013)

Molecular mode of action of NKP-1339 – a clinically investigated ruthenium-based drug – involves ER- and ROS-related effects in colon carcinoma cell lines
por: Flocke, Lea S., et al.
Publicado: (2016)

Sequence composition of disordered regions fine-tunes protein half-life
por: Fishbain, Susan, et al.
Publicado: (2015)

Cannot write session to /tmp/vufind_sessions/sess_vjtcnmtjb3afuqgjjs92mhu79j