Cardiodynamic Interactions between Two S1P(1) Receptor Modulators in an Experimental Clinical Setting: Different Pharmacokinetic Properties as an Opportunity to Mitigate First-Dose Heart Rate Effects

A decrease in heart rate (HR) is a well-established first-dose effect of sphingosine-1-phosphate subtype 1 receptor (S1P1R) modulators. For compounds with a short half-life (t(1/2)), this can be mitigated by gradual up-titration to therapeutic doses, whereas this is not required for compounds with a...

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Detalles Bibliográficos
Autores principales: Juif, Pierre-Eric, Ufer, Mike, Dingemanse, Jasper
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6651405/
https://www.ncbi.nlm.nih.gov/pubmed/31266149
http://dx.doi.org/10.3390/ijms20133232

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6651405/
https://www.ncbi.nlm.nih.gov/pubmed/31266149
http://dx.doi.org/10.3390/ijms20133232

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