Cargando…

Quantitative Biology of Human Shelterin and Telomerase: Searching for the Weakest Point

The repetitive telomeric DNA at chromosome ends is protected from unwanted repair by telomere-associated proteins, which form the shelterin complex in mammals. Recent works have provided new insights into the mechanisms of how human shelterin assembles and recruits telomerase to telomeres. Inhibitio...

Descripción completa

Detalles Bibliográficos
Autores principales:	Veverka, Pavel, Janovič, Tomáš, Hofr, Ctirad
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2019
Materias:	Review
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6651453/ https://www.ncbi.nlm.nih.gov/pubmed/31261825 http://dx.doi.org/10.3390/ijms20133186

Ejemplares similares

Electron microscopy reveals toroidal shape of master neuronal cell differentiator REST – RE1-silencing transcription factor
por: Veverka, Pavel, et al.
Publicado: (2022)

Transcriptional regulators of human oncoviruses: structural and functional implications for anticancer therapy
por: Nečasová, Ivona, et al.
Publicado: (2022)

The Shelterin TIN2 Subunit Mediates Recruitment of Telomerase to Telomeres
por: Frank, Amanda K., et al.
Publicado: (2015)

Tumor delineation: The weakest link in the search for accuracy in radiotherapy
por: Njeh, C. F.
Publicado: (2008)

Phosphorylation of TRF2 promotes its interaction with TIN2 and regulates DNA damage response at telomeres
por: Storchova, Radka, et al.
Publicado: (2023)

Reconstitution of human shelterin complexes reveals unexpected stoichiometry and dual pathways to enhance telomerase processivity
por: Lim, Ci Ji, et al.
Publicado: (2017)

Conformational plasticity and allosteric communication networks explain Shelterin protein TPP1 binding to human telomerase
por: Aureli, Simone, et al.
Publicado: (2023)

Survival of the weakest: signaling aided by endosomes
por: McShane, Marisa P., et al.
Publicado: (2008)

Chromatin Molecular Complexes—Functional Organization, Protection and Regulation of the Genome
por: Hofr, Ctirad
Publicado: (2022)

Differences in Disease Severity but Similar Telomere Lengths in Genetic Subgroups of Patients with Telomerase and Shelterin Mutations
por: Vulliamy, Tom J., et al.
Publicado: (2011)

Mitochondria in Cell Senescence: Is Mitophagy the Weakest Link?
por: Korolchuk, Viktor I., et al.
Publicado: (2017)

Finding cancer's weakest link
por: Sodir, Nicole M., et al.
Publicado: (2011)

A proto-telomere is elongated by telomerase in a shelterin-dependent manner in quiescent fission yeast cells
por: Vaurs, Mélina, et al.
Publicado: (2022)

The telosome/shelterin complex and its functions
por: Xin, Huawei, et al.
Publicado: (2008)

Shelterin Complex at Telomeres: Implications in Ageing
por: Mir, Seyed Mostafa, et al.
Publicado: (2020)

The weakest point of cardiac resynchronization therapy: new technologies facing old terminology
por: Marcantoni, Lina, et al.
Publicado: (2023)

The evolution of metazoan shelterin
por: Myler, Logan R., et al.
Publicado: (2021)

Differential Expression of Non-Shelterin Genes Associated with High Telomerase Levels and Telomere Shortening in Plasma Cell Disorders
por: Panero, Julieta, et al.
Publicado: (2015)

Basic domain of telomere guardian TRF2 reduces D-loop unwinding whereas Rap1 restores it
por: Nečasová, Ivona, et al.
Publicado: (2017)

Basic domain of telomere guardian TRF2 reduces D-loop unwinding whereas Rap1 restores it
por: Nečasová, Ivona, et al.
Publicado: (2017)

Right Knee—The Weakest Point of the Best Ultramarathon Runners of the World? A Case Study
por: Gajda, Robert, et al.
Publicado: (2020)

Managing endpoints, the weakest link in the security chain
por: Waterson, Dave
Publicado: (2020)

On the weakest falloff conditions in the metric for an isolated system
por: Petrov, A N
Publicado: (1995)

Observation of the last, weakest neutrino transformation at RENO
por: Kim, Soo-Bong
Publicado: (2012)

High‐fat diet induced obesity and age influence the telomere shelterin complex and telomerase gene expression in mouse adipose tissue
por: Bloom, Samuel I., et al.
Publicado: (2020)

Dissecting Fission Yeast Shelterin Interactions via MICro-MS Links Disruption of Shelterin Bridge to Tumorigenesis
por: Liu, Jinqiang, et al.
Publicado: (2015)

Shelterin complex gene: Prognosis and therapeutic vulnerability in cancer()
por: Bhari, Vikas Kumar, et al.
Publicado: (2021)

Shelterin protein keeps telomeres on edge
por: Leslie, Mitch
Publicado: (2013)

Shelterin reduces the accessibility of telomeric overhangs
por: Shiekh, Sajad, et al.
Publicado: (2022)

Characterization of the DNA binding specificity of Shelterin complexes
por: Choi, Kyung H., et al.
Publicado: (2011)

Managing risk by the weakest link: Are we training effectively in the heat?
por: Hunt, Andrew P, et al.
Publicado: (2015)

Gravity: how the weakest force in the universe shaped our lives
por: Clegg, Brian
Publicado: (2012)

Telomere length set point regulation in human pluripotent stem cells critically depends on the shelterin protein TPP1
por: Boyle, John M., et al.
Publicado: (2020)

Heregulin, a new interactor of the telosome/shelterin complex in human telomeres
por: Menendez, Javier A., et al.
Publicado: (2015)

Structural biology of human telomerase: progress and prospects
por: Nguyen, Thi Hoang Duong
Publicado: (2021)

SARS-CoV-2 attacks the weakest point - COVID-19 course in a pediatric patient with Friedreich's ataxia
por: Faltin, Kamil, et al.
Publicado: (2022)

Targeting the telomere and shelterin complex for cancer therapy: current views and future perspectives
por: Bilsland, Alan E, et al.
Publicado: (2011)

Multifunctionality of the Telomere-Capping Shelterin Complex Explained by Variations in Its Protein Composition
por: Ghilain, Claire, et al.
Publicado: (2021)

Shelterin is a dimeric complex with extensive structural heterogeneity
por: Zinder, John C., et al.
Publicado: (2022)

The weakest link: A new paradigm for stabilizing the integrin–actin connection
por: Morgner, Jessica, et al.
Publicado: (2013)

Cannot write session to /tmp/vufind_sessions/sess_7rgei11uj02r8i0fbii40n9mqj