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Regulation of Gene Expression under Hypoxic Conditions
Eukaryotes are often subjected to different kinds of stress. In order to adjust to such circumstances, eukaryotes activate stress–response pathways and regulate gene expression. Eukaryotic gene expression consists of many different steps, including transcription, RNA processing, RNA transport, and t...
Autores principales: | , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2019
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6651685/ https://www.ncbi.nlm.nih.gov/pubmed/31277312 http://dx.doi.org/10.3390/ijms20133278 |
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author | Nakayama, Koh Kataoka, Naoyuki |
author_facet | Nakayama, Koh Kataoka, Naoyuki |
author_sort | Nakayama, Koh |
collection | PubMed |
description | Eukaryotes are often subjected to different kinds of stress. In order to adjust to such circumstances, eukaryotes activate stress–response pathways and regulate gene expression. Eukaryotic gene expression consists of many different steps, including transcription, RNA processing, RNA transport, and translation. In this review article, we focus on both transcriptional and post-transcriptional regulations of gene expression under hypoxic conditions. In the first part of the review, transcriptional regulations mediated by various transcription factors including Hypoxia-Inducible Factors (HIFs) are described. In the second part, we present RNA splicing regulations under hypoxic conditions, which are mediated by splicing factors and their kinases. This work summarizes and discusses the emerging studies of those two gene expression machineries under hypoxic conditions. |
format | Online Article Text |
id | pubmed-6651685 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2019 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-66516852019-08-08 Regulation of Gene Expression under Hypoxic Conditions Nakayama, Koh Kataoka, Naoyuki Int J Mol Sci Review Eukaryotes are often subjected to different kinds of stress. In order to adjust to such circumstances, eukaryotes activate stress–response pathways and regulate gene expression. Eukaryotic gene expression consists of many different steps, including transcription, RNA processing, RNA transport, and translation. In this review article, we focus on both transcriptional and post-transcriptional regulations of gene expression under hypoxic conditions. In the first part of the review, transcriptional regulations mediated by various transcription factors including Hypoxia-Inducible Factors (HIFs) are described. In the second part, we present RNA splicing regulations under hypoxic conditions, which are mediated by splicing factors and their kinases. This work summarizes and discusses the emerging studies of those two gene expression machineries under hypoxic conditions. MDPI 2019-07-03 /pmc/articles/PMC6651685/ /pubmed/31277312 http://dx.doi.org/10.3390/ijms20133278 Text en © 2019 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Review Nakayama, Koh Kataoka, Naoyuki Regulation of Gene Expression under Hypoxic Conditions |
title | Regulation of Gene Expression under Hypoxic Conditions |
title_full | Regulation of Gene Expression under Hypoxic Conditions |
title_fullStr | Regulation of Gene Expression under Hypoxic Conditions |
title_full_unstemmed | Regulation of Gene Expression under Hypoxic Conditions |
title_short | Regulation of Gene Expression under Hypoxic Conditions |
title_sort | regulation of gene expression under hypoxic conditions |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6651685/ https://www.ncbi.nlm.nih.gov/pubmed/31277312 http://dx.doi.org/10.3390/ijms20133278 |
work_keys_str_mv | AT nakayamakoh regulationofgeneexpressionunderhypoxicconditions AT kataokanaoyuki regulationofgeneexpressionunderhypoxicconditions |