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Regulation of Gene Expression under Hypoxic Conditions

Eukaryotes are often subjected to different kinds of stress. In order to adjust to such circumstances, eukaryotes activate stress–response pathways and regulate gene expression. Eukaryotic gene expression consists of many different steps, including transcription, RNA processing, RNA transport, and t...

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Detalles Bibliográficos
Autores principales: Nakayama, Koh, Kataoka, Naoyuki
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6651685/
https://www.ncbi.nlm.nih.gov/pubmed/31277312
http://dx.doi.org/10.3390/ijms20133278
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author Nakayama, Koh
Kataoka, Naoyuki
author_facet Nakayama, Koh
Kataoka, Naoyuki
author_sort Nakayama, Koh
collection PubMed
description Eukaryotes are often subjected to different kinds of stress. In order to adjust to such circumstances, eukaryotes activate stress–response pathways and regulate gene expression. Eukaryotic gene expression consists of many different steps, including transcription, RNA processing, RNA transport, and translation. In this review article, we focus on both transcriptional and post-transcriptional regulations of gene expression under hypoxic conditions. In the first part of the review, transcriptional regulations mediated by various transcription factors including Hypoxia-Inducible Factors (HIFs) are described. In the second part, we present RNA splicing regulations under hypoxic conditions, which are mediated by splicing factors and their kinases. This work summarizes and discusses the emerging studies of those two gene expression machineries under hypoxic conditions.
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spelling pubmed-66516852019-08-08 Regulation of Gene Expression under Hypoxic Conditions Nakayama, Koh Kataoka, Naoyuki Int J Mol Sci Review Eukaryotes are often subjected to different kinds of stress. In order to adjust to such circumstances, eukaryotes activate stress–response pathways and regulate gene expression. Eukaryotic gene expression consists of many different steps, including transcription, RNA processing, RNA transport, and translation. In this review article, we focus on both transcriptional and post-transcriptional regulations of gene expression under hypoxic conditions. In the first part of the review, transcriptional regulations mediated by various transcription factors including Hypoxia-Inducible Factors (HIFs) are described. In the second part, we present RNA splicing regulations under hypoxic conditions, which are mediated by splicing factors and their kinases. This work summarizes and discusses the emerging studies of those two gene expression machineries under hypoxic conditions. MDPI 2019-07-03 /pmc/articles/PMC6651685/ /pubmed/31277312 http://dx.doi.org/10.3390/ijms20133278 Text en © 2019 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Nakayama, Koh
Kataoka, Naoyuki
Regulation of Gene Expression under Hypoxic Conditions
title Regulation of Gene Expression under Hypoxic Conditions
title_full Regulation of Gene Expression under Hypoxic Conditions
title_fullStr Regulation of Gene Expression under Hypoxic Conditions
title_full_unstemmed Regulation of Gene Expression under Hypoxic Conditions
title_short Regulation of Gene Expression under Hypoxic Conditions
title_sort regulation of gene expression under hypoxic conditions
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6651685/
https://www.ncbi.nlm.nih.gov/pubmed/31277312
http://dx.doi.org/10.3390/ijms20133278
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