Cargando…

Toward Rational Design of Novel Anti-Cancer Drugs Based on Targeting, Solubility, and Bioavailability Exemplified by 1,3,4-Thiadiazole Derivatives Synthesized Under Solvent-Free Conditions

The 1,3,4-thiadiazole derivatives (9a–i) were synthesized under solvent free conditions and their chemical composition was confirmed using different spectral tools (IR, Mass, and NMR spectrometry). All the synthesized compounds were screened for their anti-cancer potentiality over human breast carci...

Descripción completa

Detalles Bibliográficos
Autores principales:	Rashdan, Huda R.M., Farag, Mohammad M., El-Gendey, Marwa S., Mounier, Marwa M.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2019
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6651776/ https://www.ncbi.nlm.nih.gov/pubmed/31252614 http://dx.doi.org/10.3390/molecules24132371

Ejemplares similares

Solvent-Free Synthesis, In Vitro and In Silico Studies of Novel Potential 1,3,4-Thiadiazole-Based Molecules against Microbial Pathogens
por: Shehadi, Ihsan A., et al.
Publicado: (2022)

Synthesis and Cytotoxic Activity of New 1,3,4-Thiadiazole Thioglycosides and 1,2,3-Triazolyl-1,3,4-Thiadiazole N-glycosides
por: Alminderej, Fahad M., et al.
Publicado: (2019)

Synthesis, characterization and RHF/ab initio simulations of 2-amino-1,3,4-thiadiazole and its annulated ring junction pyrimidine derivatives
por: Hamama, Wafaa S., et al.
Publicado: (2012)

In silico study to identify novel potential thiadiazole-based molecules as anti-Covid-19 candidates by hierarchical virtual screening and molecular dynamics simulations
por: Rashdan, Huda R. M., et al.
Publicado: (2022)

1,3,4-Thiadiazole Scaffold: As Anti-Epileptic Agents
por: Anthwal, Tulika, et al.
Publicado: (2022)

Synthesis and Diuretic Activity of Substituted 1,3,4-Thiadiazoles
por: Ergena, Asrat, et al.
Publicado: (2022)

New 1,3,4-Thiadiazole Derivatives with Anticancer Activity
por: Janowska, Sara, et al.
Publicado: (2022)

Synthesis of Novel 2,5-Disubstituted-1,3,4-thiadiazoles Clubbed 1,2,4-Triazole, 1,3,4-Thiadiazole, 1,3,4-Oxadiazole and/or Schiff Base as Potential Antimicrobial and Antiproliferative Agents
por: Rezki, Nadjet, et al.
Publicado: (2015)

Bis(1,3,4-thiadiazol-2-yl) disulfide
por: Hu, Pu-Zhou, et al.
Publicado: (2009)

Cytotoxic Properties of 1,3,4-Thiadiazole Derivatives—A Review
por: Janowska, Sara, et al.
Publicado: (2020)

Synthesis and Bioactivities of Novel 1,3,4-Thiadiazole Derivatives of Glucosides
por: Chen, Meihang, et al.
Publicado: (2021)

1,3,4-Thiadiazoles Effectively Inhibit Proliferation of Toxoplasma gondii
por: Węglińska, Lidia, et al.
Publicado: (2021)

1,3,4-Thiadiazole Derivatives. Part 9(1). Synthesis and Biological Activity of Metal Complexes of 5-(2-Aminoethyl)-2-Amino-1,3,4-Thiadiazole
por: Barboiu, Mihai, et al.
Publicado: (1996)

Synthesis of (2-chloroquinolin-3-yl)-1,3,4-thiadiazole-2-carboxamides
por: Aksenov, A. N., et al.
Publicado: (2021)

New 1,3,4-thiadiazoles as potential anticancer agents: pro-apoptotic, cell cycle arrest, molecular modelling, and ADMET profile
por: Hekal, Mohamed H., et al.
Publicado: (2023)

Electrochemical study of 2-amino-5-mercapto-1,3,4-thiadiazole in the absence and presence of p-benzoquinone: an efficient strategy for the electrosynthesis of new 1,3,4-thiadiazole derivatives
por: Masoumi, Hossein, et al.
Publicado: (2023)

Synthesis and Evaluation of New 1,3,4-Thiadiazole Derivatives as Antinociceptive Agents
por: Altıntop, Mehlika Dilek, et al.
Publicado: (2016)

Synthesis and Antimicrobial Activity of Some New 1,3,4-Thiadiazole Derivatives
por: Farghaly, Thoraya A., et al.
Publicado: (2012)

Synthesis and Anticancer Activity of 1,3,4-Thiadiazoles with 3-Methoxyphenyl Substituent
por: Janowska, Sara, et al.
Publicado: (2022)

5-({3-[(5-Amino-1,3,4-thiadiazol-2-yl)sulfanylmethyl]benzyl}sulfanyl)-1,3,4-thiadiazol-2-amine
por: Kang, Sung Kwon, et al.
Publicado: (2012)

Synthesis and Antibacterial Activities of Novel Imidazo[2,1-b]-1,3,4-thiadiazoles
por: Atta, Kamal F. M., et al.
Publicado: (2011)

Comparative Study of the Synthetic Approaches and Biological Activities of the Bioisosteres of 1,3,4-Oxadiazoles and 1,3,4-Thiadiazoles over the Past Decade
por: El-Masry, Rana M., et al.
Publicado: (2022)

A facile synthesis, and antimicrobial and anticancer activities of some pyridines, thioamides, thiazole, urea, quinazoline, β-naphthyl carbamate, and pyrano[2,3-d]thiazole derivatives
por: Zaki, Yasser H., et al.
Publicado: (2018)

Synthesis, Molecular Docking Screening and Anti-Proliferative Potency Evaluation of Some New Imidazo[2,1-b]Thiazole Linked Thiadiazole Conjugates
por: Rashdan, Huda R. M., et al.
Publicado: (2020)

Novel Thiadiazole-Based Molecules as Promising Inhibitors of Black Fungi and Pathogenic Bacteria: In Vitro Antimicrobial Evaluation and Molecular Docking Studies
por: Rashdan, Huda R. M., et al.
Publicado: (2022)

Synthesis of New 1,3,4-Thiadiazole and 1,2,3,4-Oxathiadiazole Derivatives from Carbohydrate Precursors and Study of Their Effect on Tyrosinase Enzyme
por: El-Sadek, Mohamed M., et al.
Publicado: (2012)

5-(3-Nitrobenzyl)-1,3,4-thiadiazol-2-amine
por: Carvalho, Samir A., et al.
Publicado: (2009)

5-Amino-1,3,4-thiadiazol-2(3H)-one
por: Kang, Sung Kwon, et al.
Publicado: (2012)

5-(4-Pyridyl)-1,3,4-thiadiazol-2-amine
por: Wang, Yao, et al.
Publicado: (2009)

5-(3-Pyridyl)-1,3,4-thiadiazol-2-amine
por: Wang, Yao, et al.
Publicado: (2009)

5-(4-Methylphenyl)-1,3,4-thiadiazol-2-amine
por: Guan, Jian-Ning, et al.
Publicado: (2009)

3-Benzhydryl-1,3,4-thiadiazole-2(3H)-thione
por: Thornton, Megan T., et al.
Publicado: (2013)

Synthesis and biological activity of myricetin derivatives containing 1,3,4-thiadiazole scaffold
por: Zhong, Xinmin, et al.
Publicado: (2017)

Synthesis and Evaluation of New 1,3,4-Thiadiazole Derivatives as Potent Antifungal Agents
por: Karaburun, Ahmet Çağrı, et al.
Publicado: (2018)

Synthesis and Antiviral Activity of 5‑(4‑Chlorophenyl)-1,3,4-Thiadiazole Sulfonamides
por: Chen, Zhuo, et al.
Publicado: (2010)

A Novel Approach to the Synthesis of 1,3,4-Thiadiazole-2-amine Derivatives
por: Kokovina, Tatiana S., et al.
Publicado: (2021)

Synthesis and Bioactivities of Novel Galactoside Derivatives Containing 1,3,4-Thiadiazole Moiety
por: Shu, Yafei, et al.
Publicado: (2022)

Tailoring Deep Eutectic Solvents to Provoke Solubility and Bioavailability of Naringin: Implications of a Computational Approach
por: Dangre, Pankaj V., et al.
Publicado: (2023)

5-(Adamantan-1-yl)-N-methyl-1,3,4-thiadiazol-2-amine
por: Al-Tamimi, Abdul-Malek S., et al.
Publicado: (2013)

Exploring the Antiparasitic Activity of Tris-1,3,4-Thiadiazoles against Toxoplasma gondii-Infected Mice
por: Almutairi, Tahani M., et al.
Publicado: (2022)

Cannot write session to /tmp/vufind_sessions/sess_neri8oglklji05hoa1cckvt3hd