Glucocorticoid receptor modulation decreases ER-positive breast cancer cell proliferation and suppresses wild-type and mutant ER chromatin association

BACKGROUND: Non-ER nuclear receptor activity can alter estrogen receptor (ER) chromatin association and resultant ER-mediated transcription. Consistent with GR modulation of ER activity, high tumor glucocorticoid receptor (GR) expression correlates with improved relapse-free survival in ER+ breast c...

Descripción completa

Detalles Bibliográficos
Autores principales: Tonsing-Carter, Eva, Hernandez, Kyle M., Kim, Caroline R., Harkless, Ryan V., Oh, Alyce, Bowie, Kathleen R., West-Szymanski, Diana C., Betancourt-Ponce, Mayra A., Green, Bradley D., Lastra, Ricardo R., Fleming, Gini F., Chandarlapaty, Sarat, Conzen, Suzanne D.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2019
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6651939/
https://www.ncbi.nlm.nih.gov/pubmed/31340854
http://dx.doi.org/10.1186/s13058-019-1164-6

Ejemplares similares

Ejemplares similares