Cargando…

Acute Posterior Multifocal Placoid Pigment Epitheliopathy Sharing Characteristic OCT Findings of Vogt-Koyanagi-Harada Disease

A 17-year-old male presented with acute bilateral paracentral scotomata and blurred vision. Funduscopic examination showed bilateral macular serous retinal detachment and yellow-white placoid lesions at the level of retinal pigment epithelium. OCT study showed typical VKH disease findings with marke...

Descripción completa

Detalles Bibliográficos
Autores principales: Kitamura, Yuta, Oshitari, Toshiyuki, Kitahashi, Masayasu, Baba, Takayuki, Yamamoto, Shuichi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6652076/
https://www.ncbi.nlm.nih.gov/pubmed/31380133
http://dx.doi.org/10.1155/2019/9217656
_version_ 1783438493039460352
author Kitamura, Yuta
Oshitari, Toshiyuki
Kitahashi, Masayasu
Baba, Takayuki
Yamamoto, Shuichi
author_facet Kitamura, Yuta
Oshitari, Toshiyuki
Kitahashi, Masayasu
Baba, Takayuki
Yamamoto, Shuichi
author_sort Kitamura, Yuta
collection PubMed
description A 17-year-old male presented with acute bilateral paracentral scotomata and blurred vision. Funduscopic examination showed bilateral macular serous retinal detachment and yellow-white placoid lesions at the level of retinal pigment epithelium. OCT study showed typical VKH disease findings with marked choroidal thickening and macular serous retinal detachment partly with subretinal septa in both eyes. FA demonstrated hypofluorescence at the placoid lesions in the early phase and hyperfluorescence in the late phase. Laboratory investigation showed negative result for HLA-DR4 serotype and the patient's cerebrospinal fluid test values were within normal range. We made the diagnosis of APMPPE from these results. At 2-month follow-up without the use of corticosteroids, OCT reexamination showed complete amelioration of subretinal fluid in both eyes. Patchy pigmentary lesions also resolved clinically with partial chorioretinal scars. The results in this case suggested OCT findings in APMPPE patients could be similar to characteristic features usually found in acute VKH disease. We recommend comprehensive assessments such as FA, cerebral spinal fluid analysis, and HLA typing which help in leading proper diagnosis.
format Online
Article
Text
id pubmed-6652076
institution National Center for Biotechnology Information
language English
publishDate 2019
publisher Hindawi
record_format MEDLINE/PubMed
spelling pubmed-66520762019-08-04 Acute Posterior Multifocal Placoid Pigment Epitheliopathy Sharing Characteristic OCT Findings of Vogt-Koyanagi-Harada Disease Kitamura, Yuta Oshitari, Toshiyuki Kitahashi, Masayasu Baba, Takayuki Yamamoto, Shuichi Case Rep Ophthalmol Med Case Report A 17-year-old male presented with acute bilateral paracentral scotomata and blurred vision. Funduscopic examination showed bilateral macular serous retinal detachment and yellow-white placoid lesions at the level of retinal pigment epithelium. OCT study showed typical VKH disease findings with marked choroidal thickening and macular serous retinal detachment partly with subretinal septa in both eyes. FA demonstrated hypofluorescence at the placoid lesions in the early phase and hyperfluorescence in the late phase. Laboratory investigation showed negative result for HLA-DR4 serotype and the patient's cerebrospinal fluid test values were within normal range. We made the diagnosis of APMPPE from these results. At 2-month follow-up without the use of corticosteroids, OCT reexamination showed complete amelioration of subretinal fluid in both eyes. Patchy pigmentary lesions also resolved clinically with partial chorioretinal scars. The results in this case suggested OCT findings in APMPPE patients could be similar to characteristic features usually found in acute VKH disease. We recommend comprehensive assessments such as FA, cerebral spinal fluid analysis, and HLA typing which help in leading proper diagnosis. Hindawi 2019-07-09 /pmc/articles/PMC6652076/ /pubmed/31380133 http://dx.doi.org/10.1155/2019/9217656 Text en Copyright © 2019 Yuta Kitamura et al. https://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Case Report
Kitamura, Yuta
Oshitari, Toshiyuki
Kitahashi, Masayasu
Baba, Takayuki
Yamamoto, Shuichi
Acute Posterior Multifocal Placoid Pigment Epitheliopathy Sharing Characteristic OCT Findings of Vogt-Koyanagi-Harada Disease
title Acute Posterior Multifocal Placoid Pigment Epitheliopathy Sharing Characteristic OCT Findings of Vogt-Koyanagi-Harada Disease
title_full Acute Posterior Multifocal Placoid Pigment Epitheliopathy Sharing Characteristic OCT Findings of Vogt-Koyanagi-Harada Disease
title_fullStr Acute Posterior Multifocal Placoid Pigment Epitheliopathy Sharing Characteristic OCT Findings of Vogt-Koyanagi-Harada Disease
title_full_unstemmed Acute Posterior Multifocal Placoid Pigment Epitheliopathy Sharing Characteristic OCT Findings of Vogt-Koyanagi-Harada Disease
title_short Acute Posterior Multifocal Placoid Pigment Epitheliopathy Sharing Characteristic OCT Findings of Vogt-Koyanagi-Harada Disease
title_sort acute posterior multifocal placoid pigment epitheliopathy sharing characteristic oct findings of vogt-koyanagi-harada disease
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6652076/
https://www.ncbi.nlm.nih.gov/pubmed/31380133
http://dx.doi.org/10.1155/2019/9217656
work_keys_str_mv AT kitamurayuta acuteposteriormultifocalplacoidpigmentepitheliopathysharingcharacteristicoctfindingsofvogtkoyanagiharadadisease
AT oshitaritoshiyuki acuteposteriormultifocalplacoidpigmentepitheliopathysharingcharacteristicoctfindingsofvogtkoyanagiharadadisease
AT kitahashimasayasu acuteposteriormultifocalplacoidpigmentepitheliopathysharingcharacteristicoctfindingsofvogtkoyanagiharadadisease
AT babatakayuki acuteposteriormultifocalplacoidpigmentepitheliopathysharingcharacteristicoctfindingsofvogtkoyanagiharadadisease
AT yamamotoshuichi acuteposteriormultifocalplacoidpigmentepitheliopathysharingcharacteristicoctfindingsofvogtkoyanagiharadadisease