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Seminal Oxidative Stress Markers, Calcium, Magnesium, and Semen Profile of Infertile Diabetic and Nondiabetic Nigerian Men

CONTEXT: Oxidative stress, vitamin, and macroelement deficiencies have been implicated in male infertility. It is unknown if diabetes mellitus with its attendant increased oxidative stress makes the seminal quality of the diabetic infertile men worse compared to their nondiabetic counterparts. AIMS:...

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Autores principales: Bassey, Iya Eze, Isong, Idongesit Kokoabasi Paul, Sunday Esiere, Kaiso Umo, Essien, Okon Ekwerre, Udoh, Alphonsus Ekpe, Akpan, Uwem Okon
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Wolters Kluwer - Medknow 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6652280/
https://www.ncbi.nlm.nih.gov/pubmed/31392179
http://dx.doi.org/10.4103/ijabmr.IJABMR_152_18
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author Bassey, Iya Eze
Isong, Idongesit Kokoabasi Paul
Sunday Esiere, Kaiso Umo
Essien, Okon Ekwerre
Udoh, Alphonsus Ekpe
Akpan, Uwem Okon
author_facet Bassey, Iya Eze
Isong, Idongesit Kokoabasi Paul
Sunday Esiere, Kaiso Umo
Essien, Okon Ekwerre
Udoh, Alphonsus Ekpe
Akpan, Uwem Okon
author_sort Bassey, Iya Eze
collection PubMed
description CONTEXT: Oxidative stress, vitamin, and macroelement deficiencies have been implicated in male infertility. It is unknown if diabetes mellitus with its attendant increased oxidative stress makes the seminal quality of the diabetic infertile men worse compared to their nondiabetic counterparts. AIMS: The study investigated semen parameters, seminal plasma calcium, magnesium, Vitamins C and E, and total antioxidant capacity (TAC) in diabetic and nondiabetic infertile men. SETTINGS AND DESIGN: This was a cross-sectional study involving 30 infertile men with type 2 diabetes, 30 infertile nondiabetic men and 30 fertile men. SUBJECTS AND METHODS: Fasting plasma glucose, glycated hemoglobin, seminal plasma calcium, magnesium, TAC, Vitamin C, Vitamin E, semen analysis, and cultures carried out using the standard procedures. STATISTICAL ANALYSIS USED: Data were analyzed by the analysis of variance and Student's t-test; the level of significance was set at P < 0.05. RESULTS: Both infertile groups had significantly lower (P < 0.0001) sperm count, percentage motility, TAC, Vitamin E and C, magnesium and calcium when compared to the fertile group. However, there was no statistically significant difference (P > 0.05) in the mean values of these parameters among the two infertile groups. The infertile men had a significantly higher (P = 0.034) frequency of bacterial isolates compared to the fertile men. Staphylococcus aureus was the most frequent organism isolated. CONCLUSIONS: Seminal calcium, magnesium, TAC, and Vitamin E and C were lower in both infertile diabetic and nondiabetic men as compared to that of fertile men, but the levels of these analytes were comparable in the infertile diabetic and nondiabetic men.
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spelling pubmed-66522802019-08-07 Seminal Oxidative Stress Markers, Calcium, Magnesium, and Semen Profile of Infertile Diabetic and Nondiabetic Nigerian Men Bassey, Iya Eze Isong, Idongesit Kokoabasi Paul Sunday Esiere, Kaiso Umo Essien, Okon Ekwerre Udoh, Alphonsus Ekpe Akpan, Uwem Okon Int J Appl Basic Med Res Original Article CONTEXT: Oxidative stress, vitamin, and macroelement deficiencies have been implicated in male infertility. It is unknown if diabetes mellitus with its attendant increased oxidative stress makes the seminal quality of the diabetic infertile men worse compared to their nondiabetic counterparts. AIMS: The study investigated semen parameters, seminal plasma calcium, magnesium, Vitamins C and E, and total antioxidant capacity (TAC) in diabetic and nondiabetic infertile men. SETTINGS AND DESIGN: This was a cross-sectional study involving 30 infertile men with type 2 diabetes, 30 infertile nondiabetic men and 30 fertile men. SUBJECTS AND METHODS: Fasting plasma glucose, glycated hemoglobin, seminal plasma calcium, magnesium, TAC, Vitamin C, Vitamin E, semen analysis, and cultures carried out using the standard procedures. STATISTICAL ANALYSIS USED: Data were analyzed by the analysis of variance and Student's t-test; the level of significance was set at P < 0.05. RESULTS: Both infertile groups had significantly lower (P < 0.0001) sperm count, percentage motility, TAC, Vitamin E and C, magnesium and calcium when compared to the fertile group. However, there was no statistically significant difference (P > 0.05) in the mean values of these parameters among the two infertile groups. The infertile men had a significantly higher (P = 0.034) frequency of bacterial isolates compared to the fertile men. Staphylococcus aureus was the most frequent organism isolated. CONCLUSIONS: Seminal calcium, magnesium, TAC, and Vitamin E and C were lower in both infertile diabetic and nondiabetic men as compared to that of fertile men, but the levels of these analytes were comparable in the infertile diabetic and nondiabetic men. Wolters Kluwer - Medknow 2019 /pmc/articles/PMC6652280/ /pubmed/31392179 http://dx.doi.org/10.4103/ijabmr.IJABMR_152_18 Text en Copyright: © 2019 International Journal of Applied and Basic Medical Research http://creativecommons.org/licenses/by-nc-sa/4.0 This is an open access journal, and articles are distributed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike 4.0 License, which allows others to remix, tweak, and build upon the work non-commercially, as long as appropriate credit is given and the new creations are licensed under the identical terms.
spellingShingle Original Article
Bassey, Iya Eze
Isong, Idongesit Kokoabasi Paul
Sunday Esiere, Kaiso Umo
Essien, Okon Ekwerre
Udoh, Alphonsus Ekpe
Akpan, Uwem Okon
Seminal Oxidative Stress Markers, Calcium, Magnesium, and Semen Profile of Infertile Diabetic and Nondiabetic Nigerian Men
title Seminal Oxidative Stress Markers, Calcium, Magnesium, and Semen Profile of Infertile Diabetic and Nondiabetic Nigerian Men
title_full Seminal Oxidative Stress Markers, Calcium, Magnesium, and Semen Profile of Infertile Diabetic and Nondiabetic Nigerian Men
title_fullStr Seminal Oxidative Stress Markers, Calcium, Magnesium, and Semen Profile of Infertile Diabetic and Nondiabetic Nigerian Men
title_full_unstemmed Seminal Oxidative Stress Markers, Calcium, Magnesium, and Semen Profile of Infertile Diabetic and Nondiabetic Nigerian Men
title_short Seminal Oxidative Stress Markers, Calcium, Magnesium, and Semen Profile of Infertile Diabetic and Nondiabetic Nigerian Men
title_sort seminal oxidative stress markers, calcium, magnesium, and semen profile of infertile diabetic and nondiabetic nigerian men
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6652280/
https://www.ncbi.nlm.nih.gov/pubmed/31392179
http://dx.doi.org/10.4103/ijabmr.IJABMR_152_18
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