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Tissue Immune Cells Fuel Obesity-Associated Inflammation in Adipose Tissue and Beyond

Obesity-associated inflammation stems from a combination of cell-intrinsic changes of individual immune cell subsets and the dynamic crosstalk amongst a broad array of immune cells. Although much of the focus of immune cell contributions to metabolic disease has focused on adipose tissue-associated...

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Autores principales: Liu, Rui, Nikolajczyk, Barbara S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6653202/
https://www.ncbi.nlm.nih.gov/pubmed/31379820
http://dx.doi.org/10.3389/fimmu.2019.01587
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author Liu, Rui
Nikolajczyk, Barbara S.
author_facet Liu, Rui
Nikolajczyk, Barbara S.
author_sort Liu, Rui
collection PubMed
description Obesity-associated inflammation stems from a combination of cell-intrinsic changes of individual immune cell subsets and the dynamic crosstalk amongst a broad array of immune cells. Although much of the focus of immune cell contributions to metabolic disease has focused on adipose tissue-associated cells, these potent sources of inflammation inhabit other metabolic regulatory tissues, including liver and gut, and recirculate to promote systemic inflammation and thus obesity comorbidities. Tissue-associated immune cells, especially T cell subpopulations, have become a hotspot of inquiry based on their contributions to obesity, type 2 diabetes, non-alcoholic fatty liver diseases and certain types of cancers. The cell-cell interactions that take place under the stress of obesity are mediated by intracellular contact and cytokine production, and constitute a complicated network that drives the phenotypic alterations of immune cells and perpetuates a feed-forward loop of metabolic decline. Herein we discuss immune cell functions in various tissues and obesity-associated cancers from the viewpoint of inflammation. We also emphasize recent advances in the understanding of crosstalk amongst immune cell subsets under obese conditions, and suggest future directions for focused investigations with clinical relevance.
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spelling pubmed-66532022019-08-02 Tissue Immune Cells Fuel Obesity-Associated Inflammation in Adipose Tissue and Beyond Liu, Rui Nikolajczyk, Barbara S. Front Immunol Immunology Obesity-associated inflammation stems from a combination of cell-intrinsic changes of individual immune cell subsets and the dynamic crosstalk amongst a broad array of immune cells. Although much of the focus of immune cell contributions to metabolic disease has focused on adipose tissue-associated cells, these potent sources of inflammation inhabit other metabolic regulatory tissues, including liver and gut, and recirculate to promote systemic inflammation and thus obesity comorbidities. Tissue-associated immune cells, especially T cell subpopulations, have become a hotspot of inquiry based on their contributions to obesity, type 2 diabetes, non-alcoholic fatty liver diseases and certain types of cancers. The cell-cell interactions that take place under the stress of obesity are mediated by intracellular contact and cytokine production, and constitute a complicated network that drives the phenotypic alterations of immune cells and perpetuates a feed-forward loop of metabolic decline. Herein we discuss immune cell functions in various tissues and obesity-associated cancers from the viewpoint of inflammation. We also emphasize recent advances in the understanding of crosstalk amongst immune cell subsets under obese conditions, and suggest future directions for focused investigations with clinical relevance. Frontiers Media S.A. 2019-07-17 /pmc/articles/PMC6653202/ /pubmed/31379820 http://dx.doi.org/10.3389/fimmu.2019.01587 Text en Copyright © 2019 Liu and Nikolajczyk. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Immunology
Liu, Rui
Nikolajczyk, Barbara S.
Tissue Immune Cells Fuel Obesity-Associated Inflammation in Adipose Tissue and Beyond
title Tissue Immune Cells Fuel Obesity-Associated Inflammation in Adipose Tissue and Beyond
title_full Tissue Immune Cells Fuel Obesity-Associated Inflammation in Adipose Tissue and Beyond
title_fullStr Tissue Immune Cells Fuel Obesity-Associated Inflammation in Adipose Tissue and Beyond
title_full_unstemmed Tissue Immune Cells Fuel Obesity-Associated Inflammation in Adipose Tissue and Beyond
title_short Tissue Immune Cells Fuel Obesity-Associated Inflammation in Adipose Tissue and Beyond
title_sort tissue immune cells fuel obesity-associated inflammation in adipose tissue and beyond
topic Immunology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6653202/
https://www.ncbi.nlm.nih.gov/pubmed/31379820
http://dx.doi.org/10.3389/fimmu.2019.01587
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