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BAG3‐positive pancreatic stellate cells promote migration and invasion of pancreatic ductal adenocarcinoma

BAG3 is constitutively expressed in multiple types of cancer cells and its high expression is associated with tumour progression and poor prognosis of PDAC. However, little is known about the role of BAG3 in the regulation of stromal microenvironment of PDAC. The current study demonstrated that besi...

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Autores principales: Yuan, Ye, Jiang, Jing‐Yi, Wang, Jia‐Mei, Sun, Jia, Li, Chao, Liu, Bao‐Qin, Yan, Jing, Meng, Xiao‐Na, Wang, Hua‐Qin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6653255/
https://www.ncbi.nlm.nih.gov/pubmed/31119886
http://dx.doi.org/10.1111/jcmm.14352
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author Yuan, Ye
Jiang, Jing‐Yi
Wang, Jia‐Mei
Sun, Jia
Li, Chao
Liu, Bao‐Qin
Yan, Jing
Meng, Xiao‐Na
Wang, Hua‐Qin
author_facet Yuan, Ye
Jiang, Jing‐Yi
Wang, Jia‐Mei
Sun, Jia
Li, Chao
Liu, Bao‐Qin
Yan, Jing
Meng, Xiao‐Na
Wang, Hua‐Qin
author_sort Yuan, Ye
collection PubMed
description BAG3 is constitutively expressed in multiple types of cancer cells and its high expression is associated with tumour progression and poor prognosis of PDAC. However, little is known about the role of BAG3 in the regulation of stromal microenvironment of PDAC. The current study demonstrated that beside PDAC tumour cells, BAG3 was also expressed in some activated stroma cells in PDAC tissue, as well as in activated PSCs. In addition, the current study demonstrated that BAG3 expression in PSCs was involved in maintenance of PSCs activation and promotion of PDACs invasion via releasing multiple cytokines. The current study demonstrated that BAG3‐positive PSCs promoted invasion of PDACs via IL‐8, MCP1, TGF‐β2 and IGFBP2 in a paracrine manner. Furthermore, BAG3 sustained PSCs activation through IL‐6, TGF‐β2 and IGFBP2 in an autocrine manner. Thereby, the current study provides a new insight into the involvement of BAG3 in remodelling of stromal microenvironment favourable for malignant progression of PDAC, indicating that BAG3 might serve as a potential target for anti‐fibrosis of PDAC.
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spelling pubmed-66532552019-08-01 BAG3‐positive pancreatic stellate cells promote migration and invasion of pancreatic ductal adenocarcinoma Yuan, Ye Jiang, Jing‐Yi Wang, Jia‐Mei Sun, Jia Li, Chao Liu, Bao‐Qin Yan, Jing Meng, Xiao‐Na Wang, Hua‐Qin J Cell Mol Med Original Articles BAG3 is constitutively expressed in multiple types of cancer cells and its high expression is associated with tumour progression and poor prognosis of PDAC. However, little is known about the role of BAG3 in the regulation of stromal microenvironment of PDAC. The current study demonstrated that beside PDAC tumour cells, BAG3 was also expressed in some activated stroma cells in PDAC tissue, as well as in activated PSCs. In addition, the current study demonstrated that BAG3 expression in PSCs was involved in maintenance of PSCs activation and promotion of PDACs invasion via releasing multiple cytokines. The current study demonstrated that BAG3‐positive PSCs promoted invasion of PDACs via IL‐8, MCP1, TGF‐β2 and IGFBP2 in a paracrine manner. Furthermore, BAG3 sustained PSCs activation through IL‐6, TGF‐β2 and IGFBP2 in an autocrine manner. Thereby, the current study provides a new insight into the involvement of BAG3 in remodelling of stromal microenvironment favourable for malignant progression of PDAC, indicating that BAG3 might serve as a potential target for anti‐fibrosis of PDAC. John Wiley and Sons Inc. 2019-05-22 2019-08 /pmc/articles/PMC6653255/ /pubmed/31119886 http://dx.doi.org/10.1111/jcmm.14352 Text en © 2019 The Authors. Journal of Cellular and Molecular Medicine published by John Wiley & Sons Ltd and Foundation for Cellular and Molecular Medicine. This is an open access article under the terms of the http://creativecommons.org/licenses/by/4.0/ License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.
spellingShingle Original Articles
Yuan, Ye
Jiang, Jing‐Yi
Wang, Jia‐Mei
Sun, Jia
Li, Chao
Liu, Bao‐Qin
Yan, Jing
Meng, Xiao‐Na
Wang, Hua‐Qin
BAG3‐positive pancreatic stellate cells promote migration and invasion of pancreatic ductal adenocarcinoma
title BAG3‐positive pancreatic stellate cells promote migration and invasion of pancreatic ductal adenocarcinoma
title_full BAG3‐positive pancreatic stellate cells promote migration and invasion of pancreatic ductal adenocarcinoma
title_fullStr BAG3‐positive pancreatic stellate cells promote migration and invasion of pancreatic ductal adenocarcinoma
title_full_unstemmed BAG3‐positive pancreatic stellate cells promote migration and invasion of pancreatic ductal adenocarcinoma
title_short BAG3‐positive pancreatic stellate cells promote migration and invasion of pancreatic ductal adenocarcinoma
title_sort bag3‐positive pancreatic stellate cells promote migration and invasion of pancreatic ductal adenocarcinoma
topic Original Articles
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6653255/
https://www.ncbi.nlm.nih.gov/pubmed/31119886
http://dx.doi.org/10.1111/jcmm.14352
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