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Structure-Based Design, Synthesis, and Biological Evaluation of Non-Acyl Sulfamate Inhibitors of the Adenylate-Forming Enzyme MenE
N-Acyl sulfamoyladenosines (acyl-AMS) have been used extensively to inhibit adenylate-forming enzymes that are involved in a wide range of biological processes. These acyl-AMS inhibitors are nonhydrolyzable mimics of the cognate acyl adenylate intermediates that are bound tightly by adenylate-formin...
Autores principales: | Evans, Christopher E., Si, Yuanyuan, Matarlo, Joe S., Yin, Yue, French, Jarrod B., Tonge, Peter J., Tan, Derek S. |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
2019
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6653581/ https://www.ncbi.nlm.nih.gov/pubmed/30912442 http://dx.doi.org/10.1021/acs.biochem.9b00003 |
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