Basal and Spasmolytic Effects of a Hydroethanolic Leaf Extract of Melissa officinalis L. on Intestinal Motility: An Ex Vivo Study

Melissa officinalis L. (lemon balm) has been used for decades with symptomatic benefits in patients with digestive disorders. However, very little is known on the effects of M. officinalis on the gastrointestinal (GI) tract. In this study, the basal and spasmolytic properties of a hydroethanolic lea...

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Autores principales: Aubert, Philippe, Guinobert, Isabelle, Blondeau, Claude, Bardot, Valérie, Ripoche, Isabelle, Chalard, Pierre, Neunlist, Michel
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Mary Ann Liebert, Inc., publishers 2019
Materias:
Full Communications
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6653806/
https://www.ncbi.nlm.nih.gov/pubmed/30990736
http://dx.doi.org/10.1089/jmf.2018.0154
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author Aubert, Philippe
Guinobert, Isabelle
Blondeau, Claude
Bardot, Valérie
Ripoche, Isabelle
Chalard, Pierre
Neunlist, Michel
author_facet Aubert, Philippe
Guinobert, Isabelle
Blondeau, Claude
Bardot, Valérie
Ripoche, Isabelle
Chalard, Pierre
Neunlist, Michel
author_sort Aubert, Philippe
collection PubMed
description Melissa officinalis L. (lemon balm) has been used for decades with symptomatic benefits in patients with digestive disorders. However, very little is known on the effects of M. officinalis on the gastrointestinal (GI) tract. In this study, the basal and spasmolytic properties of a hydroethanolic leaf extract (HLE) of M. officinalis were assessed ex vivo on different segments of the GI tract of mice after phytochemical characterization of the extract. M. officinalis HLE had site- and dose-dependent effects on the contractile activity of the GI tract, the motility response being impacted in the jejunum and ileum but not in the antrum and colon. The observed effects could be caused by the phenolic compounds (mainly rosmarinic acid) detected in the extract.
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spelling pubmed-66538062019-07-25 Basal and Spasmolytic Effects of a Hydroethanolic Leaf Extract of Melissa officinalis L. on Intestinal Motility: An Ex Vivo Study Aubert, Philippe Guinobert, Isabelle Blondeau, Claude Bardot, Valérie Ripoche, Isabelle Chalard, Pierre Neunlist, Michel J Med Food Full Communications Melissa officinalis L. (lemon balm) has been used for decades with symptomatic benefits in patients with digestive disorders. However, very little is known on the effects of M. officinalis on the gastrointestinal (GI) tract. In this study, the basal and spasmolytic properties of a hydroethanolic leaf extract (HLE) of M. officinalis were assessed ex vivo on different segments of the GI tract of mice after phytochemical characterization of the extract. M. officinalis HLE had site- and dose-dependent effects on the contractile activity of the GI tract, the motility response being impacted in the jejunum and ileum but not in the antrum and colon. The observed effects could be caused by the phenolic compounds (mainly rosmarinic acid) detected in the extract. Mary Ann Liebert, Inc., publishers 2019-07-01 2019-07-10 /pmc/articles/PMC6653806/ /pubmed/30990736 http://dx.doi.org/10.1089/jmf.2018.0154 Text en © Philippe Aubert et al. 2019; Published by Mary Ann Liebert, Inc. This Open Access article is distributed under the terms of the Creative Commons License (http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Full Communications
Aubert, Philippe
Guinobert, Isabelle
Blondeau, Claude
Bardot, Valérie
Ripoche, Isabelle
Chalard, Pierre
Neunlist, Michel
Basal and Spasmolytic Effects of a Hydroethanolic Leaf Extract of Melissa officinalis L. on Intestinal Motility: An Ex Vivo Study
title Basal and Spasmolytic Effects of a Hydroethanolic Leaf Extract of Melissa officinalis L. on Intestinal Motility: An Ex Vivo Study
title_full Basal and Spasmolytic Effects of a Hydroethanolic Leaf Extract of Melissa officinalis L. on Intestinal Motility: An Ex Vivo Study
title_fullStr Basal and Spasmolytic Effects of a Hydroethanolic Leaf Extract of Melissa officinalis L. on Intestinal Motility: An Ex Vivo Study
title_full_unstemmed Basal and Spasmolytic Effects of a Hydroethanolic Leaf Extract of Melissa officinalis L. on Intestinal Motility: An Ex Vivo Study
title_short Basal and Spasmolytic Effects of a Hydroethanolic Leaf Extract of Melissa officinalis L. on Intestinal Motility: An Ex Vivo Study
title_sort basal and spasmolytic effects of a hydroethanolic leaf extract of melissa officinalis l. on intestinal motility: an ex vivo study
topic Full Communications
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6653806/
https://www.ncbi.nlm.nih.gov/pubmed/30990736
http://dx.doi.org/10.1089/jmf.2018.0154
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