Nintedanib ameliorates experimental pulmonary arterial hypertension via inhibition of endothelial mesenchymal transition and smooth muscle cell proliferation

Neointimal lesion and medial wall thickness of pulmonary arteries (PAs) are common pathological findings in pulmonary arterial hypertension (PAH). Platelet-derived growth factor (PDGF) and fibroblast growth factor (FGF) signaling contribute to intimal and medial vascular remodeling in PAH. Nintedani...

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Detalles Bibliográficos
Autores principales: Tsutsumi, Takeo, Nagaoka, Tetsutaro, Yoshida, Takashi, Wang, Lei, Kuriyama, Sachiko, Suzuki, Yoshifumi, Nagata, Yuichi, Harada, Norihiro, Kodama, Yuzo, Takahashi, Fumiyuki, Morio, Yoshiteru, Takahashi, Kazuhisa
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2019
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6656344/
https://www.ncbi.nlm.nih.gov/pubmed/31339889
http://dx.doi.org/10.1371/journal.pone.0214697

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