The activation of Mucolipin TRP channel 1 (TRPML1) protects motor neurons from L-BMAA neurotoxicity by promoting autophagic clearance

Cellular clearance mechanisms including the autophagy-lysosome pathway are impaired in amyotrophic lateral sclerosis (ALS). One of the most important proteins involved in the regulation of autophagy is the lysosomal Ca(2+) channel Mucolipin TRP channel 1 (TRPML1). Therefore, we investigated the role...

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Detalles Bibliográficos
Autores principales: Tedeschi, Valentina, Petrozziello, Tiziana, Sisalli, Maria José, Boscia, Francesca, Canzoniero, Lorella Maria Teresa, Secondo, Agnese
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6656764/
https://www.ncbi.nlm.nih.gov/pubmed/31341250
http://dx.doi.org/10.1038/s41598-019-46708-5

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6656764/
https://www.ncbi.nlm.nih.gov/pubmed/31341250
http://dx.doi.org/10.1038/s41598-019-46708-5

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