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Laryngeal squamous cell carcinoma and papilloma associated with Equus caballus papillomavirus 2 in a horse

A case of laryngeal squamous cell carcinoma (SCC) and squamous papilloma in a 19-year-old Thoroughbred stallion is described. The animal exhibited severe wheezing caused by laryngopharyngeal stenosis. Histological examination identified laryngeal, laryngotracheal, and guttural pouch tumor masses con...

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Autores principales: HIBI, Hiroyuki, HATAMA, Shinichi, OBATA, Atsutoshi, SHIBAHARA, Tomoyuki, KADOTA, Koichi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Japanese Society of Veterinary Science 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6656819/
https://www.ncbi.nlm.nih.gov/pubmed/31167980
http://dx.doi.org/10.1292/jvms.18-0461
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author HIBI, Hiroyuki
HATAMA, Shinichi
OBATA, Atsutoshi
SHIBAHARA, Tomoyuki
KADOTA, Koichi
author_facet HIBI, Hiroyuki
HATAMA, Shinichi
OBATA, Atsutoshi
SHIBAHARA, Tomoyuki
KADOTA, Koichi
author_sort HIBI, Hiroyuki
collection PubMed
description A case of laryngeal squamous cell carcinoma (SCC) and squamous papilloma in a 19-year-old Thoroughbred stallion is described. The animal exhibited severe wheezing caused by laryngopharyngeal stenosis. Histological examination identified laryngeal, laryngotracheal, and guttural pouch tumor masses consisting of areas of SCC. In the epiglottic lesion, the overlying epithelium was replaced by papilloma cells, and superficial cells frequently had nuclear inclusion bodies that expressed oncoprotein E6, which is characteristic of high risk human papillomaviruses. The papillomatous epithelium was continuous with epithelium composed of SCC cells. Equus caballus papillomavirus 2 (EcPV2) DNA was detected in the guttural pouch tumor. These findings suggest that laryngeal SCC and papilloma are a continuum of EcPV2-induced neoplastic lesions in horses.
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spelling pubmed-66568192019-07-31 Laryngeal squamous cell carcinoma and papilloma associated with Equus caballus papillomavirus 2 in a horse HIBI, Hiroyuki HATAMA, Shinichi OBATA, Atsutoshi SHIBAHARA, Tomoyuki KADOTA, Koichi J Vet Med Sci Pathology A case of laryngeal squamous cell carcinoma (SCC) and squamous papilloma in a 19-year-old Thoroughbred stallion is described. The animal exhibited severe wheezing caused by laryngopharyngeal stenosis. Histological examination identified laryngeal, laryngotracheal, and guttural pouch tumor masses consisting of areas of SCC. In the epiglottic lesion, the overlying epithelium was replaced by papilloma cells, and superficial cells frequently had nuclear inclusion bodies that expressed oncoprotein E6, which is characteristic of high risk human papillomaviruses. The papillomatous epithelium was continuous with epithelium composed of SCC cells. Equus caballus papillomavirus 2 (EcPV2) DNA was detected in the guttural pouch tumor. These findings suggest that laryngeal SCC and papilloma are a continuum of EcPV2-induced neoplastic lesions in horses. The Japanese Society of Veterinary Science 2019-06-04 2019-07 /pmc/articles/PMC6656819/ /pubmed/31167980 http://dx.doi.org/10.1292/jvms.18-0461 Text en ©2019 The Japanese Society of Veterinary Science This is an open-access article distributed under the terms of the Creative Commons Attribution Non-Commercial No Derivatives (by-nc-nd) License. (CC-BY-NC-ND 4.0: https://creativecommons.org/licenses/by-nc-nd/4.0/)
spellingShingle Pathology
HIBI, Hiroyuki
HATAMA, Shinichi
OBATA, Atsutoshi
SHIBAHARA, Tomoyuki
KADOTA, Koichi
Laryngeal squamous cell carcinoma and papilloma associated with Equus caballus papillomavirus 2 in a horse
title Laryngeal squamous cell carcinoma and papilloma associated with Equus caballus papillomavirus 2 in a horse
title_full Laryngeal squamous cell carcinoma and papilloma associated with Equus caballus papillomavirus 2 in a horse
title_fullStr Laryngeal squamous cell carcinoma and papilloma associated with Equus caballus papillomavirus 2 in a horse
title_full_unstemmed Laryngeal squamous cell carcinoma and papilloma associated with Equus caballus papillomavirus 2 in a horse
title_short Laryngeal squamous cell carcinoma and papilloma associated with Equus caballus papillomavirus 2 in a horse
title_sort laryngeal squamous cell carcinoma and papilloma associated with equus caballus papillomavirus 2 in a horse
topic Pathology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6656819/
https://www.ncbi.nlm.nih.gov/pubmed/31167980
http://dx.doi.org/10.1292/jvms.18-0461
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