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Laryngeal squamous cell carcinoma and papilloma associated with Equus caballus papillomavirus 2 in a horse
A case of laryngeal squamous cell carcinoma (SCC) and squamous papilloma in a 19-year-old Thoroughbred stallion is described. The animal exhibited severe wheezing caused by laryngopharyngeal stenosis. Histological examination identified laryngeal, laryngotracheal, and guttural pouch tumor masses con...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
The Japanese Society of Veterinary Science
2019
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6656819/ https://www.ncbi.nlm.nih.gov/pubmed/31167980 http://dx.doi.org/10.1292/jvms.18-0461 |
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author | HIBI, Hiroyuki HATAMA, Shinichi OBATA, Atsutoshi SHIBAHARA, Tomoyuki KADOTA, Koichi |
author_facet | HIBI, Hiroyuki HATAMA, Shinichi OBATA, Atsutoshi SHIBAHARA, Tomoyuki KADOTA, Koichi |
author_sort | HIBI, Hiroyuki |
collection | PubMed |
description | A case of laryngeal squamous cell carcinoma (SCC) and squamous papilloma in a 19-year-old Thoroughbred stallion is described. The animal exhibited severe wheezing caused by laryngopharyngeal stenosis. Histological examination identified laryngeal, laryngotracheal, and guttural pouch tumor masses consisting of areas of SCC. In the epiglottic lesion, the overlying epithelium was replaced by papilloma cells, and superficial cells frequently had nuclear inclusion bodies that expressed oncoprotein E6, which is characteristic of high risk human papillomaviruses. The papillomatous epithelium was continuous with epithelium composed of SCC cells. Equus caballus papillomavirus 2 (EcPV2) DNA was detected in the guttural pouch tumor. These findings suggest that laryngeal SCC and papilloma are a continuum of EcPV2-induced neoplastic lesions in horses. |
format | Online Article Text |
id | pubmed-6656819 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2019 |
publisher | The Japanese Society of Veterinary Science |
record_format | MEDLINE/PubMed |
spelling | pubmed-66568192019-07-31 Laryngeal squamous cell carcinoma and papilloma associated with Equus caballus papillomavirus 2 in a horse HIBI, Hiroyuki HATAMA, Shinichi OBATA, Atsutoshi SHIBAHARA, Tomoyuki KADOTA, Koichi J Vet Med Sci Pathology A case of laryngeal squamous cell carcinoma (SCC) and squamous papilloma in a 19-year-old Thoroughbred stallion is described. The animal exhibited severe wheezing caused by laryngopharyngeal stenosis. Histological examination identified laryngeal, laryngotracheal, and guttural pouch tumor masses consisting of areas of SCC. In the epiglottic lesion, the overlying epithelium was replaced by papilloma cells, and superficial cells frequently had nuclear inclusion bodies that expressed oncoprotein E6, which is characteristic of high risk human papillomaviruses. The papillomatous epithelium was continuous with epithelium composed of SCC cells. Equus caballus papillomavirus 2 (EcPV2) DNA was detected in the guttural pouch tumor. These findings suggest that laryngeal SCC and papilloma are a continuum of EcPV2-induced neoplastic lesions in horses. The Japanese Society of Veterinary Science 2019-06-04 2019-07 /pmc/articles/PMC6656819/ /pubmed/31167980 http://dx.doi.org/10.1292/jvms.18-0461 Text en ©2019 The Japanese Society of Veterinary Science This is an open-access article distributed under the terms of the Creative Commons Attribution Non-Commercial No Derivatives (by-nc-nd) License. (CC-BY-NC-ND 4.0: https://creativecommons.org/licenses/by-nc-nd/4.0/) |
spellingShingle | Pathology HIBI, Hiroyuki HATAMA, Shinichi OBATA, Atsutoshi SHIBAHARA, Tomoyuki KADOTA, Koichi Laryngeal squamous cell carcinoma and papilloma associated with Equus caballus papillomavirus 2 in a horse |
title | Laryngeal squamous cell carcinoma and papilloma associated with Equus caballus papillomavirus 2 in a horse |
title_full | Laryngeal squamous cell carcinoma and papilloma associated with Equus caballus papillomavirus 2 in a horse |
title_fullStr | Laryngeal squamous cell carcinoma and papilloma associated with Equus caballus papillomavirus 2 in a horse |
title_full_unstemmed | Laryngeal squamous cell carcinoma and papilloma associated with Equus caballus papillomavirus 2 in a horse |
title_short | Laryngeal squamous cell carcinoma and papilloma associated with Equus caballus papillomavirus 2 in a horse |
title_sort | laryngeal squamous cell carcinoma and papilloma associated with equus caballus papillomavirus 2 in a horse |
topic | Pathology |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6656819/ https://www.ncbi.nlm.nih.gov/pubmed/31167980 http://dx.doi.org/10.1292/jvms.18-0461 |
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