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Successful treatment based on molecular biological assessment of invasive anaplastic lymphoma kinase-positive inflammatory myofibroblastic tumor of the lung

BACKGROUND: Inflammatory myofibroblastic tumor (IMT) of the lung is rare. This disease often shows neoplastic features with anaplastic lymphoma kinase positiveness as well as inflammatory features, such as steroid-responsive immunoglobulin G4 (IgG4)-related sclerosing disease. Since many cases have...

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Autores principales: Watanabe, Hironosuke, Yamasaki, Naoya, Miyazaki, Takuro, Matsumoto, Keitaro, Tsuchiya, Tomoshi, Abe, Kuniko, Nagayasu, Takeshi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Berlin Heidelberg 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6656828/
https://www.ncbi.nlm.nih.gov/pubmed/31342196
http://dx.doi.org/10.1186/s40792-019-0674-x
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author Watanabe, Hironosuke
Yamasaki, Naoya
Miyazaki, Takuro
Matsumoto, Keitaro
Tsuchiya, Tomoshi
Abe, Kuniko
Nagayasu, Takeshi
author_facet Watanabe, Hironosuke
Yamasaki, Naoya
Miyazaki, Takuro
Matsumoto, Keitaro
Tsuchiya, Tomoshi
Abe, Kuniko
Nagayasu, Takeshi
author_sort Watanabe, Hironosuke
collection PubMed
description BACKGROUND: Inflammatory myofibroblastic tumor (IMT) of the lung is rare. This disease often shows neoplastic features with anaplastic lymphoma kinase positiveness as well as inflammatory features, such as steroid-responsive immunoglobulin G4 (IgG4)-related sclerosing disease. Since many cases have been reported as advanced, various treatment strategies should be considered based on clinical and biological features of each case. CASE PRESENTATION: We report a 49-year-old male with IMT, which seemed invading the left atrium from preoperative imaging modalities. Serological and pathological examinations from the biopsy specimen revealed high expression of anaplastic lymphoma kinase expression in the tumor. On the other hand, IgG4/IgG ration in the tumor was small, where a therapeutic effect of steroid was not expected, leading to surgical treatment rather than a steroid administration. The tumor was completely resected en bloc with the right lower lobe of the lung and a part of the left atrium. The postoperative course of the patient was uneventful. The patient has remained recurrence free over 5 years from the surgery. CONCLUSION: In this case, preoperative biological assessment prior to the treatment led to a good clinical course. We believe that molecular biological examination is important in the determination of treatment strategy for this rare disease as well as imaging modalities.
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spelling pubmed-66568282019-08-07 Successful treatment based on molecular biological assessment of invasive anaplastic lymphoma kinase-positive inflammatory myofibroblastic tumor of the lung Watanabe, Hironosuke Yamasaki, Naoya Miyazaki, Takuro Matsumoto, Keitaro Tsuchiya, Tomoshi Abe, Kuniko Nagayasu, Takeshi Surg Case Rep Case Report BACKGROUND: Inflammatory myofibroblastic tumor (IMT) of the lung is rare. This disease often shows neoplastic features with anaplastic lymphoma kinase positiveness as well as inflammatory features, such as steroid-responsive immunoglobulin G4 (IgG4)-related sclerosing disease. Since many cases have been reported as advanced, various treatment strategies should be considered based on clinical and biological features of each case. CASE PRESENTATION: We report a 49-year-old male with IMT, which seemed invading the left atrium from preoperative imaging modalities. Serological and pathological examinations from the biopsy specimen revealed high expression of anaplastic lymphoma kinase expression in the tumor. On the other hand, IgG4/IgG ration in the tumor was small, where a therapeutic effect of steroid was not expected, leading to surgical treatment rather than a steroid administration. The tumor was completely resected en bloc with the right lower lobe of the lung and a part of the left atrium. The postoperative course of the patient was uneventful. The patient has remained recurrence free over 5 years from the surgery. CONCLUSION: In this case, preoperative biological assessment prior to the treatment led to a good clinical course. We believe that molecular biological examination is important in the determination of treatment strategy for this rare disease as well as imaging modalities. Springer Berlin Heidelberg 2019-07-24 /pmc/articles/PMC6656828/ /pubmed/31342196 http://dx.doi.org/10.1186/s40792-019-0674-x Text en © The Author(s). 2019 Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made.
spellingShingle Case Report
Watanabe, Hironosuke
Yamasaki, Naoya
Miyazaki, Takuro
Matsumoto, Keitaro
Tsuchiya, Tomoshi
Abe, Kuniko
Nagayasu, Takeshi
Successful treatment based on molecular biological assessment of invasive anaplastic lymphoma kinase-positive inflammatory myofibroblastic tumor of the lung
title Successful treatment based on molecular biological assessment of invasive anaplastic lymphoma kinase-positive inflammatory myofibroblastic tumor of the lung
title_full Successful treatment based on molecular biological assessment of invasive anaplastic lymphoma kinase-positive inflammatory myofibroblastic tumor of the lung
title_fullStr Successful treatment based on molecular biological assessment of invasive anaplastic lymphoma kinase-positive inflammatory myofibroblastic tumor of the lung
title_full_unstemmed Successful treatment based on molecular biological assessment of invasive anaplastic lymphoma kinase-positive inflammatory myofibroblastic tumor of the lung
title_short Successful treatment based on molecular biological assessment of invasive anaplastic lymphoma kinase-positive inflammatory myofibroblastic tumor of the lung
title_sort successful treatment based on molecular biological assessment of invasive anaplastic lymphoma kinase-positive inflammatory myofibroblastic tumor of the lung
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6656828/
https://www.ncbi.nlm.nih.gov/pubmed/31342196
http://dx.doi.org/10.1186/s40792-019-0674-x
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