Circulating MicroRNAs in Cancer: Potential and Challenge

MicroRNAs (miRNAs) are endogenous non-coding small RNA molecules that can be secreted into the circulation and exist in remarkably stable forms. Like intercellular miRNAs, circulating miRNAs participate in numerous regulations of biological process and expressed aberrantly under abnormal or patholog...

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Autores principales: Cui, Mengying, Wang, Hongdan, Yao, Xiaoxiao, Zhang, Dan, Xie, Yingjun, Cui, Ranji, Zhang, Xuewen
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2019
Materias:
Genetics
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6656856/
https://www.ncbi.nlm.nih.gov/pubmed/31379918
http://dx.doi.org/10.3389/fgene.2019.00626
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author Cui, Mengying
Wang, Hongdan
Yao, Xiaoxiao
Zhang, Dan
Xie, Yingjun
Cui, Ranji
Zhang, Xuewen
author_facet Cui, Mengying
Wang, Hongdan
Yao, Xiaoxiao
Zhang, Dan
Xie, Yingjun
Cui, Ranji
Zhang, Xuewen
author_sort Cui, Mengying
collection PubMed
description MicroRNAs (miRNAs) are endogenous non-coding small RNA molecules that can be secreted into the circulation and exist in remarkably stable forms. Like intercellular miRNAs, circulating miRNAs participate in numerous regulations of biological process and expressed aberrantly under abnormal or pathological status. The quality and quantity changes of circulating miRNAs are associated with the initiation and progression of cancer and can be easily detected by basic molecular biology techniques. Consequently, considerable effort has been devoted to identify suitable extracellular miRNAs for noninvasive biomarkers in cancer. However, several challenges need to be overcome before the practical application. In this review, we discuss several issues of circulating miRNAs: biological function and basic transport carriers; extracellular cell communication process; roles as reliable cancer biomarkers and usage in targeted cancer therapy; and challenges for clinical application.
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spelling pubmed-66568562019-08-02 Circulating MicroRNAs in Cancer: Potential and Challenge Cui, Mengying Wang, Hongdan Yao, Xiaoxiao Zhang, Dan Xie, Yingjun Cui, Ranji Zhang, Xuewen Front Genet Genetics MicroRNAs (miRNAs) are endogenous non-coding small RNA molecules that can be secreted into the circulation and exist in remarkably stable forms. Like intercellular miRNAs, circulating miRNAs participate in numerous regulations of biological process and expressed aberrantly under abnormal or pathological status. The quality and quantity changes of circulating miRNAs are associated with the initiation and progression of cancer and can be easily detected by basic molecular biology techniques. Consequently, considerable effort has been devoted to identify suitable extracellular miRNAs for noninvasive biomarkers in cancer. However, several challenges need to be overcome before the practical application. In this review, we discuss several issues of circulating miRNAs: biological function and basic transport carriers; extracellular cell communication process; roles as reliable cancer biomarkers and usage in targeted cancer therapy; and challenges for clinical application. Frontiers Media S.A. 2019-07-18 /pmc/articles/PMC6656856/ /pubmed/31379918 http://dx.doi.org/10.3389/fgene.2019.00626 Text en Copyright © 2019 Cui, Wang, Yao, Zhang, Xie, Cui, and Zhang http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Genetics
Cui, Mengying
Wang, Hongdan
Yao, Xiaoxiao
Zhang, Dan
Xie, Yingjun
Cui, Ranji
Zhang, Xuewen
Circulating MicroRNAs in Cancer: Potential and Challenge
title Circulating MicroRNAs in Cancer: Potential and Challenge
title_full Circulating MicroRNAs in Cancer: Potential and Challenge
title_fullStr Circulating MicroRNAs in Cancer: Potential and Challenge
title_full_unstemmed Circulating MicroRNAs in Cancer: Potential and Challenge
title_short Circulating MicroRNAs in Cancer: Potential and Challenge
title_sort circulating micrornas in cancer: potential and challenge
topic Genetics
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6656856/
https://www.ncbi.nlm.nih.gov/pubmed/31379918
http://dx.doi.org/10.3389/fgene.2019.00626
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AT xieyingjun circulatingmicrornasincancerpotentialandchallenge
AT cuiranji circulatingmicrornasincancerpotentialandchallenge
AT zhangxuewen circulatingmicrornasincancerpotentialandchallenge

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