A Comprehensive Framework for Physiologically‐Based Pharmacokinetic Modeling in Matlab

Physiologically‐based pharmacokinetic (PBPK) models are useful tools to predict clinical scenarios for special populations for whom there are high hurdles to conduct clinical trials such as children or the elderly. However, the coding of a PBPK model in a mathematical programming language can be cha...

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Detalles Bibliográficos
Autores principales: Stader, Felix, Penny, Melissa A., Siccardi, Marco, Marzolini, Catia
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2019
Materias:
Tutorial
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6657005/
https://www.ncbi.nlm.nih.gov/pubmed/30779335
http://dx.doi.org/10.1002/psp4.12399
Descripción
Sumario:Physiologically‐based pharmacokinetic (PBPK) models are useful tools to predict clinical scenarios for special populations for whom there are high hurdles to conduct clinical trials such as children or the elderly. However, the coding of a PBPK model in a mathematical programming language can be challenging. This tutorial illustrates how to build a whole‐body PBPK model in Matlab to answer specific pharmacological questions involving drug disposition and magnitudes of drug–drug interactions in different patient populations.

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