A Comprehensive Framework for Physiologically‐Based Pharmacokinetic Modeling in Matlab

Physiologically‐based pharmacokinetic (PBPK) models are useful tools to predict clinical scenarios for special populations for whom there are high hurdles to conduct clinical trials such as children or the elderly. However, the coding of a PBPK model in a mathematical programming language can be cha...

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Detalles Bibliográficos
Autores principales: Stader, Felix, Penny, Melissa A., Siccardi, Marco, Marzolini, Catia
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2019
Materias:
Tutorial
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6657005/
https://www.ncbi.nlm.nih.gov/pubmed/30779335
http://dx.doi.org/10.1002/psp4.12399
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author Stader, Felix
Penny, Melissa A.
Siccardi, Marco
Marzolini, Catia
author_facet Stader, Felix
Penny, Melissa A.
Siccardi, Marco
Marzolini, Catia
author_sort Stader, Felix
collection PubMed
description Physiologically‐based pharmacokinetic (PBPK) models are useful tools to predict clinical scenarios for special populations for whom there are high hurdles to conduct clinical trials such as children or the elderly. However, the coding of a PBPK model in a mathematical programming language can be challenging. This tutorial illustrates how to build a whole‐body PBPK model in Matlab to answer specific pharmacological questions involving drug disposition and magnitudes of drug–drug interactions in different patient populations.
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spelling pubmed-66570052019-07-31 A Comprehensive Framework for Physiologically‐Based Pharmacokinetic Modeling in Matlab Stader, Felix Penny, Melissa A. Siccardi, Marco Marzolini, Catia CPT Pharmacometrics Syst Pharmacol Tutorial Physiologically‐based pharmacokinetic (PBPK) models are useful tools to predict clinical scenarios for special populations for whom there are high hurdles to conduct clinical trials such as children or the elderly. However, the coding of a PBPK model in a mathematical programming language can be challenging. This tutorial illustrates how to build a whole‐body PBPK model in Matlab to answer specific pharmacological questions involving drug disposition and magnitudes of drug–drug interactions in different patient populations. John Wiley and Sons Inc. 2019-04-02 2019-07 /pmc/articles/PMC6657005/ /pubmed/30779335 http://dx.doi.org/10.1002/psp4.12399 Text en © 2019 The Authors CPT: Pharmacometrics & Systems Pharmacology published by Wiley Periodicals, Inc. on behalf of the American Society for Clinical Pharmacology and Therapeutics. This is an open access article under the terms of the http://creativecommons.org/licenses/by-nc/4.0/ License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited and is not used for commercial purposes.
spellingShingle Tutorial
Stader, Felix
Penny, Melissa A.
Siccardi, Marco
Marzolini, Catia
A Comprehensive Framework for Physiologically‐Based Pharmacokinetic Modeling in Matlab
title A Comprehensive Framework for Physiologically‐Based Pharmacokinetic Modeling in Matlab
title_full A Comprehensive Framework for Physiologically‐Based Pharmacokinetic Modeling in Matlab
title_fullStr A Comprehensive Framework for Physiologically‐Based Pharmacokinetic Modeling in Matlab
title_full_unstemmed A Comprehensive Framework for Physiologically‐Based Pharmacokinetic Modeling in Matlab
title_short A Comprehensive Framework for Physiologically‐Based Pharmacokinetic Modeling in Matlab
title_sort comprehensive framework for physiologically‐based pharmacokinetic modeling in matlab
topic Tutorial
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6657005/
https://www.ncbi.nlm.nih.gov/pubmed/30779335
http://dx.doi.org/10.1002/psp4.12399
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