Elevated neoantigen levels in tumors with somatic mutations in the HLA-A, HLA-B, HLA-C and B2M genes

BACKGROUND: The major histocompatibility complex class I (MHC-I) molecule is a protein complex that displays intracellular peptides to T cells, allowing the immune system to recognize and destroy infected or cancerous cells. MHC-I is composed of a highly polymorphic HLA-encoded alpha chain that bind...

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Detalles Bibliográficos
Autores principales: Castro, Andrea, Ozturk, Kivilcim, Pyke, Rachel Marty, Xian, Su, Zanetti, Maurizio, Carter, Hannah
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2019
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6657029/
https://www.ncbi.nlm.nih.gov/pubmed/31345234
http://dx.doi.org/10.1186/s12920-019-0544-1

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6657029/
https://www.ncbi.nlm.nih.gov/pubmed/31345234
http://dx.doi.org/10.1186/s12920-019-0544-1

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