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Allergic contact dermatitis of both eyes caused by alcaftadine 0.25%: a case report

BACKGROUND: To report the first case of allergic contact dermatitis (ACD) associated with alcaftadine 0.25% ophthalmic solution. CASE PRESENTATION: The patient was a 51-year-old woman with no previous history of side effects to ophthalmic antihistamine agents. She had been prescribed alcaftadine 0.2...

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Autores principales: Kim, Jae Hyuk, Kim, Hyun Joon, Kim, Sun Woong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6657074/
https://www.ncbi.nlm.nih.gov/pubmed/31340775
http://dx.doi.org/10.1186/s12886-019-1166-2
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author Kim, Jae Hyuk
Kim, Hyun Joon
Kim, Sun Woong
author_facet Kim, Jae Hyuk
Kim, Hyun Joon
Kim, Sun Woong
author_sort Kim, Jae Hyuk
collection PubMed
description BACKGROUND: To report the first case of allergic contact dermatitis (ACD) associated with alcaftadine 0.25% ophthalmic solution. CASE PRESENTATION: The patient was a 51-year-old woman with no previous history of side effects to ophthalmic antihistamine agents. She had been prescribed alcaftadine 0.25% for allergic conjunctivitis. On first application of the medication, she did not experience any cutaneous reaction. One day later, after the second alcaftadine 0.25% application, both eyelids became swollen, and erythematous changes were evident. On slit-lamp examination, conjunctival injection was noted in the absence of conjunctival swelling or any other findings. Fundus examination was unremarkable. To evaluate the cause of ACD, a patch test was performed and 48 h later was noted to be positive for alcaftadine 0.25%. Based on the positive patch test, the patient was diagnosed with ACD caused by alcaftadine 0.25%. After 9 days of treatment, the swelling and erythema completely resolved. CONCLUSIONS: Although there have been no previous reports of alcaftadine 0.25%-associated ACD, it should be suspected in patients with swelling and erythematous change of both eyes after using alcaftadine 0.25%.
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spelling pubmed-66570742019-07-31 Allergic contact dermatitis of both eyes caused by alcaftadine 0.25%: a case report Kim, Jae Hyuk Kim, Hyun Joon Kim, Sun Woong BMC Ophthalmol Case Report BACKGROUND: To report the first case of allergic contact dermatitis (ACD) associated with alcaftadine 0.25% ophthalmic solution. CASE PRESENTATION: The patient was a 51-year-old woman with no previous history of side effects to ophthalmic antihistamine agents. She had been prescribed alcaftadine 0.25% for allergic conjunctivitis. On first application of the medication, she did not experience any cutaneous reaction. One day later, after the second alcaftadine 0.25% application, both eyelids became swollen, and erythematous changes were evident. On slit-lamp examination, conjunctival injection was noted in the absence of conjunctival swelling or any other findings. Fundus examination was unremarkable. To evaluate the cause of ACD, a patch test was performed and 48 h later was noted to be positive for alcaftadine 0.25%. Based on the positive patch test, the patient was diagnosed with ACD caused by alcaftadine 0.25%. After 9 days of treatment, the swelling and erythema completely resolved. CONCLUSIONS: Although there have been no previous reports of alcaftadine 0.25%-associated ACD, it should be suspected in patients with swelling and erythematous change of both eyes after using alcaftadine 0.25%. BioMed Central 2019-07-24 /pmc/articles/PMC6657074/ /pubmed/31340775 http://dx.doi.org/10.1186/s12886-019-1166-2 Text en © The Author(s). 2019 Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.
spellingShingle Case Report
Kim, Jae Hyuk
Kim, Hyun Joon
Kim, Sun Woong
Allergic contact dermatitis of both eyes caused by alcaftadine 0.25%: a case report
title Allergic contact dermatitis of both eyes caused by alcaftadine 0.25%: a case report
title_full Allergic contact dermatitis of both eyes caused by alcaftadine 0.25%: a case report
title_fullStr Allergic contact dermatitis of both eyes caused by alcaftadine 0.25%: a case report
title_full_unstemmed Allergic contact dermatitis of both eyes caused by alcaftadine 0.25%: a case report
title_short Allergic contact dermatitis of both eyes caused by alcaftadine 0.25%: a case report
title_sort allergic contact dermatitis of both eyes caused by alcaftadine 0.25%: a case report
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6657074/
https://www.ncbi.nlm.nih.gov/pubmed/31340775
http://dx.doi.org/10.1186/s12886-019-1166-2
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