Complement factor C5 inhibition reduces type 2 responses without affecting group 2 innate lymphoid cells in a house dust mite induced murine asthma model

BACKGROUND: Complement factor C5 can either aggravate or attenuate the T-helper type 2 (T(H)2) immune response and airway hyperresponsiveness (AHR) in murine models of allergic asthma. The effect of C5 during the effector phase of allergen-induced asthma is ill-defined. OBJECTIVES: We aimed to deter...

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Detalles Bibliográficos
Autores principales: Yang, Jack, Ramirez Moral, Ivan, van ’t Veer, Cornelis, de Vos, Alex F., de Beer, Regina, Roelofs, Joris J. T. H., Morgan, B. Paul, van der Poll, Tom
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2019
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6657208/
https://www.ncbi.nlm.nih.gov/pubmed/31340811
http://dx.doi.org/10.1186/s12931-019-1136-5

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