Orally bioavailable glutamine antagonist prodrug JHU-083 penetrates mouse brain and suppresses the growth of MYC-driven medulloblastoma()()

A subset of poor-prognosis medulloblastoma has genomic amplification of MYC. MYC regulates glutamine metabolism in multiple cellular contexts. We modified the glutamine analog 6-diazo-5-oxo-l-norleucine (DON) to mask its carboxylate and amine functionalities, creating a prodrug termed JHU-083 with i...

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Detalles Bibliográficos
Autores principales: Hanaford, Allison R., Alt, Jesse, Rais, Rana, Wang, Sabrina Z., Kaur, Harpreet, Thorek, Daniel L.J., Eberhart, Charles G., Slusher, Barbara S., Martin, Allison M., Raabe, Eric H.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Neoplasia Press 2019
Materias:
Original article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6657308/
https://www.ncbi.nlm.nih.gov/pubmed/31340195
http://dx.doi.org/10.1016/j.tranon.2019.05.013

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