Human Artificial Chromosomes that Bypass Centromeric DNA

Recent breakthroughs with synthetic budding yeast chromosomes expedite the creation of synthetic mammalian chromosomes and genomes. Mammals, unlike budding yeast, depend on the histone H3 variant, CENP-A, to epigenetically specify the location of the centromere—the locus essential for chromosome seg...

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Detalles Bibliográficos
Autores principales: Logsdon, Glennis A., Gambogi, Craig W., Liskovykh, Mikhail A., Barrey, Evelyne J., Larionov, Vladimir, Miga, Karen H., Heun, Patrick, Black, Ben E.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cell Press 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6657561/
https://www.ncbi.nlm.nih.gov/pubmed/31348889
http://dx.doi.org/10.1016/j.cell.2019.06.006

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