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A CRISPR/Cas9 Whole-Genome Screen Identifies Genes Required for Aryl Hydrocarbon Receptor-Dependent Induction of Functional CYP1A1

Environmental pollutants including halogenated aromatic hydrocarbons and polycyclic aromatic hydrocarbons, including benzo[a]pyrene, exert their deleterious effects through the activation of the aryl hydrocarbon receptor (AHR) and by the resulting transcription of genes not yet fully identified. Lig...

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Detalles Bibliográficos
Autores principales:	Sundberg, Christopher D, Hankinson, Oliver
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Oxford University Press 2019
Materias:	Computational Toxicology and Databases
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6657581/ https://www.ncbi.nlm.nih.gov/pubmed/31086989 http://dx.doi.org/10.1093/toxsci/kfz111

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