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Tumor Microenvironment and Cell Fusion

Cell fusion is a highly regulated biological process that occurs under both physiological and pathological conditions. The cellular and extracellular environment is critical for the induction of the cell–cell fusion. Aberrant cell fusion is initiated during tumor progression. Tumor microenvironment...

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Detalles Bibliográficos
Autores principales: Jiang, Erhui, Yan, Tinglin, Xu, Zhi, Shang, Zhengjun
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6657644/
https://www.ncbi.nlm.nih.gov/pubmed/31380426
http://dx.doi.org/10.1155/2019/5013592
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author Jiang, Erhui
Yan, Tinglin
Xu, Zhi
Shang, Zhengjun
author_facet Jiang, Erhui
Yan, Tinglin
Xu, Zhi
Shang, Zhengjun
author_sort Jiang, Erhui
collection PubMed
description Cell fusion is a highly regulated biological process that occurs under both physiological and pathological conditions. The cellular and extracellular environment is critical for the induction of the cell–cell fusion. Aberrant cell fusion is initiated during tumor progression. Tumor microenvironment is a complex dynamic system formed by the interaction between tumor cells and their surrounding cells. Cell–cell fusion mediates direct interaction between tumor cells and their surrounding cells and is associated with tumor initiation and progression. Various microenvironmental factors affect cell fusion in tumor microenvironment and generate hybrids that acquire genomes of both parental cells and exhibit novel characteristics, such as tumor stem cell-like properties, radioresistance, drug resistance, immune evasion, and enhanced migration and invasion abilities, which are closely related to the initiation, invasion, and metastasis of tumor. The phenotypic characteristics of hybrids are based on the phenotypes of parental cells, and the fusion of tumor cells with diverse types of microenvironmental fusogenic cells is concomitant with phenotypic heterogeneity. This review highlights the types of fusogenic cells in tumor microenvironment that can fuse with tumor cells and their specific significance and summarizes the various microenvironmental factors affecting tumor cell fusion. This review may be used as a reference to develop strategies for future research on tumor cell fusion and the exploration of cell fusion-based antitumor therapies.
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spelling pubmed-66576442019-08-04 Tumor Microenvironment and Cell Fusion Jiang, Erhui Yan, Tinglin Xu, Zhi Shang, Zhengjun Biomed Res Int Review Article Cell fusion is a highly regulated biological process that occurs under both physiological and pathological conditions. The cellular and extracellular environment is critical for the induction of the cell–cell fusion. Aberrant cell fusion is initiated during tumor progression. Tumor microenvironment is a complex dynamic system formed by the interaction between tumor cells and their surrounding cells. Cell–cell fusion mediates direct interaction between tumor cells and their surrounding cells and is associated with tumor initiation and progression. Various microenvironmental factors affect cell fusion in tumor microenvironment and generate hybrids that acquire genomes of both parental cells and exhibit novel characteristics, such as tumor stem cell-like properties, radioresistance, drug resistance, immune evasion, and enhanced migration and invasion abilities, which are closely related to the initiation, invasion, and metastasis of tumor. The phenotypic characteristics of hybrids are based on the phenotypes of parental cells, and the fusion of tumor cells with diverse types of microenvironmental fusogenic cells is concomitant with phenotypic heterogeneity. This review highlights the types of fusogenic cells in tumor microenvironment that can fuse with tumor cells and their specific significance and summarizes the various microenvironmental factors affecting tumor cell fusion. This review may be used as a reference to develop strategies for future research on tumor cell fusion and the exploration of cell fusion-based antitumor therapies. Hindawi 2019-07-11 /pmc/articles/PMC6657644/ /pubmed/31380426 http://dx.doi.org/10.1155/2019/5013592 Text en Copyright © 2019 Erhui Jiang et al. https://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Review Article
Jiang, Erhui
Yan, Tinglin
Xu, Zhi
Shang, Zhengjun
Tumor Microenvironment and Cell Fusion
title Tumor Microenvironment and Cell Fusion
title_full Tumor Microenvironment and Cell Fusion
title_fullStr Tumor Microenvironment and Cell Fusion
title_full_unstemmed Tumor Microenvironment and Cell Fusion
title_short Tumor Microenvironment and Cell Fusion
title_sort tumor microenvironment and cell fusion
topic Review Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6657644/
https://www.ncbi.nlm.nih.gov/pubmed/31380426
http://dx.doi.org/10.1155/2019/5013592
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