Cargando…

Increased expression of caspase 1 during active phase of connective tissue disease

Key factors of pyroptosis play an important role in the inflammatory response to connective tissue disease (CTD). However, information on active and stable stages of CTD is scarce. To distinguish the differences of concentrations of C-reactive protein (CRP), caspase 1, caspase 4, caspase 5 and sCD14...

Descripción completa

Detalles Bibliográficos
Autores principales: Cai, Rentian, Wang, Qiongqiong, Zhu, Gongmin, Zhu, Liying, Tao, Zhen
Formato: Online Artículo Texto
Lenguaje:English
Publicado: PeerJ Inc. 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6657674/
https://www.ncbi.nlm.nih.gov/pubmed/31367484
http://dx.doi.org/10.7717/peerj.7321
_version_ 1783438832812687360
author Cai, Rentian
Wang, Qiongqiong
Zhu, Gongmin
Zhu, Liying
Tao, Zhen
author_facet Cai, Rentian
Wang, Qiongqiong
Zhu, Gongmin
Zhu, Liying
Tao, Zhen
author_sort Cai, Rentian
collection PubMed
description Key factors of pyroptosis play an important role in the inflammatory response to connective tissue disease (CTD). However, information on active and stable stages of CTD is scarce. To distinguish the differences of concentrations of C-reactive protein (CRP), caspase 1, caspase 4, caspase 5 and sCD14 in plasma between the patients with active and stable stages of CTD. A cohort study was conducted to recruit patients diagnosed with CTD of active phase and stable phase as well as health control. These data included the analysis of the concentration of sCD14, caspase 1, caspase 4 and caspase 5 in peripheral plasma by ELISA. The Wilcoxon rank-sum test was used to compare the two groups. The sex ratio and ages of the three groups were not different statistically. The concentrations of sCD14, caspase4 and caspase5 of plasma in the CTD of active phase and the stable phase as well as the health control. The concentration of caspase 1 in active phase of CTD (470.19 [422.33–513.14] pmol/L) was significantly higher than that in stable group (203.95 [160.94–236.12] pmol/L) and healthy control (201.65 [191.11–240.35] pmol/L] pmol/L) (p < 0.001, both), but there was no significant difference between stable group and healthy control (p = 0.2312). Similarly, the concentration of CRP in the active phase of CTD (8.96 [3.06–20.28] mg/L) was significantly higher than that in the stable group (3.00 [1.30–11.40] mg/L) and the healthy control (3.70 [2.30–4.73] mg/L) (p = 0.0013, p = 0.0006, respectively), but there was no significant difference between the stable group and the healthy control (p = 0.3205). However, there were no significant differences in the concentration of sCD14, caspase 4 and caspase 5 in the active phase of CTD and the stable group as well as the health group. Consequently, the patients of the active phase of CTD showed increased expression of caspase 1.
format Online
Article
Text
id pubmed-6657674
institution National Center for Biotechnology Information
language English
publishDate 2019
publisher PeerJ Inc.
record_format MEDLINE/PubMed
spelling pubmed-66576742019-07-31 Increased expression of caspase 1 during active phase of connective tissue disease Cai, Rentian Wang, Qiongqiong Zhu, Gongmin Zhu, Liying Tao, Zhen PeerJ Epidemiology Key factors of pyroptosis play an important role in the inflammatory response to connective tissue disease (CTD). However, information on active and stable stages of CTD is scarce. To distinguish the differences of concentrations of C-reactive protein (CRP), caspase 1, caspase 4, caspase 5 and sCD14 in plasma between the patients with active and stable stages of CTD. A cohort study was conducted to recruit patients diagnosed with CTD of active phase and stable phase as well as health control. These data included the analysis of the concentration of sCD14, caspase 1, caspase 4 and caspase 5 in peripheral plasma by ELISA. The Wilcoxon rank-sum test was used to compare the two groups. The sex ratio and ages of the three groups were not different statistically. The concentrations of sCD14, caspase4 and caspase5 of plasma in the CTD of active phase and the stable phase as well as the health control. The concentration of caspase 1 in active phase of CTD (470.19 [422.33–513.14] pmol/L) was significantly higher than that in stable group (203.95 [160.94–236.12] pmol/L) and healthy control (201.65 [191.11–240.35] pmol/L] pmol/L) (p < 0.001, both), but there was no significant difference between stable group and healthy control (p = 0.2312). Similarly, the concentration of CRP in the active phase of CTD (8.96 [3.06–20.28] mg/L) was significantly higher than that in the stable group (3.00 [1.30–11.40] mg/L) and the healthy control (3.70 [2.30–4.73] mg/L) (p = 0.0013, p = 0.0006, respectively), but there was no significant difference between the stable group and the healthy control (p = 0.3205). However, there were no significant differences in the concentration of sCD14, caspase 4 and caspase 5 in the active phase of CTD and the stable group as well as the health group. Consequently, the patients of the active phase of CTD showed increased expression of caspase 1. PeerJ Inc. 2019-07-22 /pmc/articles/PMC6657674/ /pubmed/31367484 http://dx.doi.org/10.7717/peerj.7321 Text en ©2019 Cai et al. https://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use, distribution, reproduction and adaptation in any medium and for any purpose provided that it is properly attributed. For attribution, the original author(s), title, publication source (PeerJ) and either DOI or URL of the article must be cited.
spellingShingle Epidemiology
Cai, Rentian
Wang, Qiongqiong
Zhu, Gongmin
Zhu, Liying
Tao, Zhen
Increased expression of caspase 1 during active phase of connective tissue disease
title Increased expression of caspase 1 during active phase of connective tissue disease
title_full Increased expression of caspase 1 during active phase of connective tissue disease
title_fullStr Increased expression of caspase 1 during active phase of connective tissue disease
title_full_unstemmed Increased expression of caspase 1 during active phase of connective tissue disease
title_short Increased expression of caspase 1 during active phase of connective tissue disease
title_sort increased expression of caspase 1 during active phase of connective tissue disease
topic Epidemiology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6657674/
https://www.ncbi.nlm.nih.gov/pubmed/31367484
http://dx.doi.org/10.7717/peerj.7321
work_keys_str_mv AT cairentian increasedexpressionofcaspase1duringactivephaseofconnectivetissuedisease
AT wangqiongqiong increasedexpressionofcaspase1duringactivephaseofconnectivetissuedisease
AT zhugongmin increasedexpressionofcaspase1duringactivephaseofconnectivetissuedisease
AT zhuliying increasedexpressionofcaspase1duringactivephaseofconnectivetissuedisease
AT taozhen increasedexpressionofcaspase1duringactivephaseofconnectivetissuedisease