Dexmedetomidine-induced cardioprotection is mediated by inhibition of high mobility group box-1 and the cholinergic anti-inflammatory pathway in myocardial ischemia-reperfusion injury

OBJECTIVES: Dexmedetomidine (DEX) is a selective α2-adrenoceptor agonist that has anti-inflammatory and cardioprotective effects in myocardial ischemia/reperfusion (I/R) injury. The present study aimed to investigate the underlying mechanism by which DEX protects against myocardial I/R. METHODS: Spr...

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Detalles Bibliográficos
Autores principales: Zhang, Juan, Xia, Fan, Zhao, Haifeng, Peng, Ke, Liu, Huayue, Meng, Xiaowen, Chen, Chen, Ji, Fuhai
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2019
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6657822/
https://www.ncbi.nlm.nih.gov/pubmed/31344138
http://dx.doi.org/10.1371/journal.pone.0218726

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