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Quantifying immune-based counterselection of somatic mutations

Somatic mutations in protein-coding regions can generate ‘neoantigens’ causing developing cancers to be eliminated by the immune system. Quantitative estimates of the strength of this counterselection phenomenon have been lacking. We quantified the extent to which somatic mutations are depleted in p...

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Detalles Bibliográficos
Autores principales:	Yang, Fan, Kim, Dae-Kyum, Nakagawa, Hidewaki, Hayashi, Shuto, Imoto, Seiya, Stein, Lincoln, Roth, Frederick P.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2019
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6657826/ https://www.ncbi.nlm.nih.gov/pubmed/31344031 http://dx.doi.org/10.1371/journal.pgen.1008227

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