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Polyvinyl alcohol cryogel phantoms of biological tissues for wideband operation at microwave frequencies

The aim of this work is to provide a methodology to model the dielectric properties of human tissues based on phantoms prepared with an aqueous solution, in a semi-solid form, by using off-the-shelf components. Polyvinyl alcohol cryogel (PVA-C) has been employed as a novel gelling agent in the fabri...

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Autores principales: Arteaga-Marrero, Natalia, Villa, Enrique, González-Fernández, Javier, Martín, Yolanda, Ruiz-Alzola, Juan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6657873/
https://www.ncbi.nlm.nih.gov/pubmed/31344092
http://dx.doi.org/10.1371/journal.pone.0219997
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author Arteaga-Marrero, Natalia
Villa, Enrique
González-Fernández, Javier
Martín, Yolanda
Ruiz-Alzola, Juan
author_facet Arteaga-Marrero, Natalia
Villa, Enrique
González-Fernández, Javier
Martín, Yolanda
Ruiz-Alzola, Juan
author_sort Arteaga-Marrero, Natalia
collection PubMed
description The aim of this work is to provide a methodology to model the dielectric properties of human tissues based on phantoms prepared with an aqueous solution, in a semi-solid form, by using off-the-shelf components. Polyvinyl alcohol cryogel (PVA-C) has been employed as a novel gelling agent in the fabrication of phantoms for microwave applications in a wide frequency range, from 500 MHz to 20 GHz. Agar-based and deionized water phantoms have also been manufactured for comparison purposes. Mathematical models dependent on frequency and sucrose concentration are proposed to obtain the complex permittivity of the desired mimicked tissues. These models have been validated in the referred bandwidth showing a good agreement to experimental data for different sucrose concentrations. The PVA-C model provides a great performance as compared to agar, increasing the shelf-life of the phantoms and improving their consistency for contact-required devices. In addition, the feasibility of fabricating a multilayer phantom has been demonstrated with a two-layer phantom that exhibits a clear interface between each layer and its properties. Thus, the use of PVA-C extends the option for producing complex multilayer and multimodal phantoms.
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spelling pubmed-66578732019-08-07 Polyvinyl alcohol cryogel phantoms of biological tissues for wideband operation at microwave frequencies Arteaga-Marrero, Natalia Villa, Enrique González-Fernández, Javier Martín, Yolanda Ruiz-Alzola, Juan PLoS One Research Article The aim of this work is to provide a methodology to model the dielectric properties of human tissues based on phantoms prepared with an aqueous solution, in a semi-solid form, by using off-the-shelf components. Polyvinyl alcohol cryogel (PVA-C) has been employed as a novel gelling agent in the fabrication of phantoms for microwave applications in a wide frequency range, from 500 MHz to 20 GHz. Agar-based and deionized water phantoms have also been manufactured for comparison purposes. Mathematical models dependent on frequency and sucrose concentration are proposed to obtain the complex permittivity of the desired mimicked tissues. These models have been validated in the referred bandwidth showing a good agreement to experimental data for different sucrose concentrations. The PVA-C model provides a great performance as compared to agar, increasing the shelf-life of the phantoms and improving their consistency for contact-required devices. In addition, the feasibility of fabricating a multilayer phantom has been demonstrated with a two-layer phantom that exhibits a clear interface between each layer and its properties. Thus, the use of PVA-C extends the option for producing complex multilayer and multimodal phantoms. Public Library of Science 2019-07-25 /pmc/articles/PMC6657873/ /pubmed/31344092 http://dx.doi.org/10.1371/journal.pone.0219997 Text en © 2019 Arteaga-Marrero et al http://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
spellingShingle Research Article
Arteaga-Marrero, Natalia
Villa, Enrique
González-Fernández, Javier
Martín, Yolanda
Ruiz-Alzola, Juan
Polyvinyl alcohol cryogel phantoms of biological tissues for wideband operation at microwave frequencies
title Polyvinyl alcohol cryogel phantoms of biological tissues for wideband operation at microwave frequencies
title_full Polyvinyl alcohol cryogel phantoms of biological tissues for wideband operation at microwave frequencies
title_fullStr Polyvinyl alcohol cryogel phantoms of biological tissues for wideband operation at microwave frequencies
title_full_unstemmed Polyvinyl alcohol cryogel phantoms of biological tissues for wideband operation at microwave frequencies
title_short Polyvinyl alcohol cryogel phantoms of biological tissues for wideband operation at microwave frequencies
title_sort polyvinyl alcohol cryogel phantoms of biological tissues for wideband operation at microwave frequencies
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6657873/
https://www.ncbi.nlm.nih.gov/pubmed/31344092
http://dx.doi.org/10.1371/journal.pone.0219997
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