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Performance of the TIMI risk score in predicting mortality after primary percutaneous coronary intervention in elderly women: Results from a developing country

BACKGROUND: Despite women undergoing primary percutaneous coronary intervention (PPCI) having a higher rate of adverse outcomes than men, data evaluating prognostic risk scores, especially in elderly women, remains scarce. This study was conducted to validate the predictive value of Thrombolysis in...

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Autores principales: Furnaz, Shumaila, Karim, Musa, Ashraf, Tariq, Ali, Sajjad, Shahid, Izza, Ali, Sara, Khawaja, Uzzam Ahmed, Haque, Muhammad Tanzeel ul, Usman, Muhammad Shariq, Siddiqi, Tariq Jamal
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6657879/
https://www.ncbi.nlm.nih.gov/pubmed/31344139
http://dx.doi.org/10.1371/journal.pone.0220289
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author Furnaz, Shumaila
Karim, Musa
Ashraf, Tariq
Ali, Sajjad
Shahid, Izza
Ali, Sara
Khawaja, Uzzam Ahmed
Haque, Muhammad Tanzeel ul
Usman, Muhammad Shariq
Siddiqi, Tariq Jamal
author_facet Furnaz, Shumaila
Karim, Musa
Ashraf, Tariq
Ali, Sajjad
Shahid, Izza
Ali, Sara
Khawaja, Uzzam Ahmed
Haque, Muhammad Tanzeel ul
Usman, Muhammad Shariq
Siddiqi, Tariq Jamal
author_sort Furnaz, Shumaila
collection PubMed
description BACKGROUND: Despite women undergoing primary percutaneous coronary intervention (PPCI) having a higher rate of adverse outcomes than men, data evaluating prognostic risk scores, especially in elderly women, remains scarce. This study was conducted to validate the predictive value of Thrombolysis in Myocardial Infarction (TIMI) risk score in elderly female patients. MATERIALS AND METHODS: This was a retrospective analysis of elderly (>65 years) female patients who underwent PPCI for ST-elevated myocardial infarction (STEMI) from October 2016 to September 2018. Patients’ demographic details and elements of TIMI risk score including age, co-morbidities, Killip classification; weight, anterior MI and total ischemic time were extracted from hospital records. The primary outcome was in-hospital mortality and post-discharge mortality reported on telephonic follow-up. RESULTS: A total of 404 elderly women with a median age of 70 years were included. The mean TIMI score was 5.25±1.45 with 40.3% (163) patients of TIMI score > 5. In-hospital mortality rate was 6.4% (26) and was found to be associated with TIMI score (p<0.001). The in-hospital mortality rate increased from 3.1% at TIMI score of 0–4 to 34.6% at the score of 8. On follow-up (16.43±7.40 months) of 211 (55.8%) patients, the overall mortality rate was 20.3%, and this was also associated with TIMI score (p<0.001). The mortality rate increased from 5.6% at the score of 0–4 to 54.5% at the score of 8. The predictive values (area under the curve) of TIMI risk score for in-hospital and post-discharge mortality were 0.709 (95% CI 0.591–0.827; p <0.001) and 0.689 (95% CI 0.608–0.770; p <0.001), respectively. CONCLUSION: Increased adverse outcomes were observed with higher TIMI risk score for in hospital and post-discharge follow-up. Therefore, the prognostic TIMI risk score is a robust tool in predicting both in-hospital as well as post-discharge mortality in elderly females.
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spelling pubmed-66578792019-08-07 Performance of the TIMI risk score in predicting mortality after primary percutaneous coronary intervention in elderly women: Results from a developing country Furnaz, Shumaila Karim, Musa Ashraf, Tariq Ali, Sajjad Shahid, Izza Ali, Sara Khawaja, Uzzam Ahmed Haque, Muhammad Tanzeel ul Usman, Muhammad Shariq Siddiqi, Tariq Jamal PLoS One Research Article BACKGROUND: Despite women undergoing primary percutaneous coronary intervention (PPCI) having a higher rate of adverse outcomes than men, data evaluating prognostic risk scores, especially in elderly women, remains scarce. This study was conducted to validate the predictive value of Thrombolysis in Myocardial Infarction (TIMI) risk score in elderly female patients. MATERIALS AND METHODS: This was a retrospective analysis of elderly (>65 years) female patients who underwent PPCI for ST-elevated myocardial infarction (STEMI) from October 2016 to September 2018. Patients’ demographic details and elements of TIMI risk score including age, co-morbidities, Killip classification; weight, anterior MI and total ischemic time were extracted from hospital records. The primary outcome was in-hospital mortality and post-discharge mortality reported on telephonic follow-up. RESULTS: A total of 404 elderly women with a median age of 70 years were included. The mean TIMI score was 5.25±1.45 with 40.3% (163) patients of TIMI score > 5. In-hospital mortality rate was 6.4% (26) and was found to be associated with TIMI score (p<0.001). The in-hospital mortality rate increased from 3.1% at TIMI score of 0–4 to 34.6% at the score of 8. On follow-up (16.43±7.40 months) of 211 (55.8%) patients, the overall mortality rate was 20.3%, and this was also associated with TIMI score (p<0.001). The mortality rate increased from 5.6% at the score of 0–4 to 54.5% at the score of 8. The predictive values (area under the curve) of TIMI risk score for in-hospital and post-discharge mortality were 0.709 (95% CI 0.591–0.827; p <0.001) and 0.689 (95% CI 0.608–0.770; p <0.001), respectively. CONCLUSION: Increased adverse outcomes were observed with higher TIMI risk score for in hospital and post-discharge follow-up. Therefore, the prognostic TIMI risk score is a robust tool in predicting both in-hospital as well as post-discharge mortality in elderly females. Public Library of Science 2019-07-25 /pmc/articles/PMC6657879/ /pubmed/31344139 http://dx.doi.org/10.1371/journal.pone.0220289 Text en © 2019 Furnaz et al http://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
spellingShingle Research Article
Furnaz, Shumaila
Karim, Musa
Ashraf, Tariq
Ali, Sajjad
Shahid, Izza
Ali, Sara
Khawaja, Uzzam Ahmed
Haque, Muhammad Tanzeel ul
Usman, Muhammad Shariq
Siddiqi, Tariq Jamal
Performance of the TIMI risk score in predicting mortality after primary percutaneous coronary intervention in elderly women: Results from a developing country
title Performance of the TIMI risk score in predicting mortality after primary percutaneous coronary intervention in elderly women: Results from a developing country
title_full Performance of the TIMI risk score in predicting mortality after primary percutaneous coronary intervention in elderly women: Results from a developing country
title_fullStr Performance of the TIMI risk score in predicting mortality after primary percutaneous coronary intervention in elderly women: Results from a developing country
title_full_unstemmed Performance of the TIMI risk score in predicting mortality after primary percutaneous coronary intervention in elderly women: Results from a developing country
title_short Performance of the TIMI risk score in predicting mortality after primary percutaneous coronary intervention in elderly women: Results from a developing country
title_sort performance of the timi risk score in predicting mortality after primary percutaneous coronary intervention in elderly women: results from a developing country
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6657879/
https://www.ncbi.nlm.nih.gov/pubmed/31344139
http://dx.doi.org/10.1371/journal.pone.0220289
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