Attenuation of chronic antiviral T-cell responses through constitutive COX2-dependent prostanoid synthesis by lymph node fibroblasts

Lymphoid T-zone fibroblastic reticular cells (FRCs) actively promote T-cell trafficking, homeostasis, and expansion but can also attenuate excessive T-cell responses via inducible nitric oxide (NO) and constitutive prostanoid release. It remains unclear how these FRC-derived mediators dampen T-cell...

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Detalles Bibliográficos
Autores principales: Schaeuble, Karin, Cannelle, Hélène, Favre, Stéphanie, Huang, Hsin-Ying, Oberle, Susanne G., Speiser, Daniel E., Zehn, Dietmar, Luther, Sanjiv A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2019
Materias:
Short Reports
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6657915/
https://www.ncbi.nlm.nih.gov/pubmed/31306410
http://dx.doi.org/10.1371/journal.pbio.3000072

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