Exosomes containing HIV protein Nef reorganize lipid rafts potentiating inflammatory response in bystander cells

HIV infection has a profound effect on “bystander” cells causing metabolic co-morbidities. This may be mediated by exosomes secreted by HIV-infected cells and containing viral factors. Here we show that exosomes containing HIV-1 protein Nef (exNef) are rapidly taken up by macrophages releasing Nef i...

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Detalles Bibliográficos
Autores principales: Mukhamedova, Nigora, Hoang, Anh, Dragoljevic, Dragana, Dubrovsky, Larisa, Pushkarsky, Tatiana, Low, Hann, Ditiatkovski, Michael, Fu, Ying, Ohkawa, Ryunosuke, Meikle, Peter J., Horvath, Anelia, Brichacek, Beda, Miller, Yury I., Murphy, Andrew, Bukrinsky, Michael, Sviridov, Dmitri
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2019
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6657916/
https://www.ncbi.nlm.nih.gov/pubmed/31344124
http://dx.doi.org/10.1371/journal.ppat.1007907

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