Cargando…

Clinical evaluation for morbidity associated with soil-transmitted helminth infection in school-age children on Pemba Island, Tanzania

BACKGROUND: More than 1.5 billion people are infected with soil-transmitted helminths (Ascaris lumbricoides, hookworm, Strongyloides stercoralis, and Trichuris trichiura), causing an estimated global burden in excess of 3 million disability-adjusted life years. However, the relationship between soil...

Descripción completa

Detalles Bibliográficos
Autores principales: Bogoch, Isaac I., Speich, Benjamin, Lo, Nathan C., Moser, Wendelin, Croll, David, Ali, Said M., Ame, Shaali M., Utzinger, Jürg, Andrews, Jason R., Keiser, Jennifer
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6658009/
https://www.ncbi.nlm.nih.gov/pubmed/31306433
http://dx.doi.org/10.1371/journal.pntd.0007581
_version_ 1783438893141458944
author Bogoch, Isaac I.
Speich, Benjamin
Lo, Nathan C.
Moser, Wendelin
Croll, David
Ali, Said M.
Ame, Shaali M.
Utzinger, Jürg
Andrews, Jason R.
Keiser, Jennifer
author_facet Bogoch, Isaac I.
Speich, Benjamin
Lo, Nathan C.
Moser, Wendelin
Croll, David
Ali, Said M.
Ame, Shaali M.
Utzinger, Jürg
Andrews, Jason R.
Keiser, Jennifer
author_sort Bogoch, Isaac I.
collection PubMed
description BACKGROUND: More than 1.5 billion people are infected with soil-transmitted helminths (Ascaris lumbricoides, hookworm, Strongyloides stercoralis, and Trichuris trichiura), causing an estimated global burden in excess of 3 million disability-adjusted life years. However, the relationship between soil-transmitted helminth infection, adverse health consequences, and beneficial effects of deworming are not well understood. METHODOLOGY: We pursued a detailed longitudinal clinical evaluation of school-age children to evaluate morbidity associated with soil-transmitted helminth infection and responses to treatment. This exploratory study was embedded into a randomized controlled trial. Overall, 434 children, aged 7–14 years, underwent a detailed medical history, physical examination, stool microscopy for soil-transmitted helminths, and hemoglobin (Hb) measurement at baseline. Medical history and stool examination were repeated at 3 and 18 weeks posttreatment. Additionally, Hb measurement was performed at the 18-week treatment follow-up. Logistic regression was employed to assess clinical factors associated with soil-transmitted helminth infection at baseline, and longitudinal data analysis to examine change in health outcomes following treatment over time. PRINCIPAL FINDINGS: All enrolled children were infected with T. trichiura, and randomized into four different treatment interventions. None of the medical history, physical examination, and laboratory (i.e., Hb) findings were associated with A. lumbricoides, hookworm, or S. stercoralis infection at baseline. A composite of physical exam findings for anemia, including pallor of the conjunctiva, nail beds, and palmar creases predicted lower Hb values (-3.8 g/dl, 95% confidence interval (CI): -6.9, -0.6 g/dl). When examining longitudinal trends, we did not find improvements to Hb or face Wong-Baker Likert scale among children with soil-transmitted helminth infection compared to those without infection, although there was a slight trend toward improving Hb values after treating hookworm infection. CONCLUSIONS/SIGNIFICANCE: Our study demonstrates the challenges of measuring morbidity in the context of soil-transmitted helminth infection and treatment, thus confirming the mainly subtle morbidity effects of infection.
format Online
Article
Text
id pubmed-6658009
institution National Center for Biotechnology Information
language English
publishDate 2019
publisher Public Library of Science
record_format MEDLINE/PubMed
spelling pubmed-66580092019-08-06 Clinical evaluation for morbidity associated with soil-transmitted helminth infection in school-age children on Pemba Island, Tanzania Bogoch, Isaac I. Speich, Benjamin Lo, Nathan C. Moser, Wendelin Croll, David Ali, Said M. Ame, Shaali M. Utzinger, Jürg Andrews, Jason R. Keiser, Jennifer PLoS Negl Trop Dis Research Article BACKGROUND: More than 1.5 billion people are infected with soil-transmitted helminths (Ascaris lumbricoides, hookworm, Strongyloides stercoralis, and Trichuris trichiura), causing an estimated global burden in excess of 3 million disability-adjusted life years. However, the relationship between soil-transmitted helminth infection, adverse health consequences, and beneficial effects of deworming are not well understood. METHODOLOGY: We pursued a detailed longitudinal clinical evaluation of school-age children to evaluate morbidity associated with soil-transmitted helminth infection and responses to treatment. This exploratory study was embedded into a randomized controlled trial. Overall, 434 children, aged 7–14 years, underwent a detailed medical history, physical examination, stool microscopy for soil-transmitted helminths, and hemoglobin (Hb) measurement at baseline. Medical history and stool examination were repeated at 3 and 18 weeks posttreatment. Additionally, Hb measurement was performed at the 18-week treatment follow-up. Logistic regression was employed to assess clinical factors associated with soil-transmitted helminth infection at baseline, and longitudinal data analysis to examine change in health outcomes following treatment over time. PRINCIPAL FINDINGS: All enrolled children were infected with T. trichiura, and randomized into four different treatment interventions. None of the medical history, physical examination, and laboratory (i.e., Hb) findings were associated with A. lumbricoides, hookworm, or S. stercoralis infection at baseline. A composite of physical exam findings for anemia, including pallor of the conjunctiva, nail beds, and palmar creases predicted lower Hb values (-3.8 g/dl, 95% confidence interval (CI): -6.9, -0.6 g/dl). When examining longitudinal trends, we did not find improvements to Hb or face Wong-Baker Likert scale among children with soil-transmitted helminth infection compared to those without infection, although there was a slight trend toward improving Hb values after treating hookworm infection. CONCLUSIONS/SIGNIFICANCE: Our study demonstrates the challenges of measuring morbidity in the context of soil-transmitted helminth infection and treatment, thus confirming the mainly subtle morbidity effects of infection. Public Library of Science 2019-07-15 /pmc/articles/PMC6658009/ /pubmed/31306433 http://dx.doi.org/10.1371/journal.pntd.0007581 Text en © 2019 Bogoch et al http://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
spellingShingle Research Article
Bogoch, Isaac I.
Speich, Benjamin
Lo, Nathan C.
Moser, Wendelin
Croll, David
Ali, Said M.
Ame, Shaali M.
Utzinger, Jürg
Andrews, Jason R.
Keiser, Jennifer
Clinical evaluation for morbidity associated with soil-transmitted helminth infection in school-age children on Pemba Island, Tanzania
title Clinical evaluation for morbidity associated with soil-transmitted helminth infection in school-age children on Pemba Island, Tanzania
title_full Clinical evaluation for morbidity associated with soil-transmitted helminth infection in school-age children on Pemba Island, Tanzania
title_fullStr Clinical evaluation for morbidity associated with soil-transmitted helminth infection in school-age children on Pemba Island, Tanzania
title_full_unstemmed Clinical evaluation for morbidity associated with soil-transmitted helminth infection in school-age children on Pemba Island, Tanzania
title_short Clinical evaluation for morbidity associated with soil-transmitted helminth infection in school-age children on Pemba Island, Tanzania
title_sort clinical evaluation for morbidity associated with soil-transmitted helminth infection in school-age children on pemba island, tanzania
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6658009/
https://www.ncbi.nlm.nih.gov/pubmed/31306433
http://dx.doi.org/10.1371/journal.pntd.0007581
work_keys_str_mv AT bogochisaaci clinicalevaluationformorbidityassociatedwithsoiltransmittedhelminthinfectioninschoolagechildrenonpembaislandtanzania
AT speichbenjamin clinicalevaluationformorbidityassociatedwithsoiltransmittedhelminthinfectioninschoolagechildrenonpembaislandtanzania
AT lonathanc clinicalevaluationformorbidityassociatedwithsoiltransmittedhelminthinfectioninschoolagechildrenonpembaislandtanzania
AT moserwendelin clinicalevaluationformorbidityassociatedwithsoiltransmittedhelminthinfectioninschoolagechildrenonpembaislandtanzania
AT crolldavid clinicalevaluationformorbidityassociatedwithsoiltransmittedhelminthinfectioninschoolagechildrenonpembaislandtanzania
AT alisaidm clinicalevaluationformorbidityassociatedwithsoiltransmittedhelminthinfectioninschoolagechildrenonpembaislandtanzania
AT ameshaalim clinicalevaluationformorbidityassociatedwithsoiltransmittedhelminthinfectioninschoolagechildrenonpembaislandtanzania
AT utzingerjurg clinicalevaluationformorbidityassociatedwithsoiltransmittedhelminthinfectioninschoolagechildrenonpembaislandtanzania
AT andrewsjasonr clinicalevaluationformorbidityassociatedwithsoiltransmittedhelminthinfectioninschoolagechildrenonpembaislandtanzania
AT keiserjennifer clinicalevaluationformorbidityassociatedwithsoiltransmittedhelminthinfectioninschoolagechildrenonpembaislandtanzania