Distal Ileal Ulcers as Gastrointestinal Manifestation of Waldenstrom Macroglobulinemia

Waldenstrom macroglobulinemia (WM) is a neoplastic disorder of the B-cell lymphoid system. A 69-year-old man with WM presented with diarrhea for 6 months. Magnetic resonance enterography showed thickening of the terminal ileum (TI). Colonosocopy with TI intubation showed a single TI ulcer, and small...

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Autores principales: Kantamaneni, Vamsi, Gurram, Krishna, Khehra, Raman, Koneru, Gopala, Kulkarni, Abhijit
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Wolters Kluwer 2019
Materias:
Case Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6658042/
https://www.ncbi.nlm.nih.gov/pubmed/31616739
http://dx.doi.org/10.14309/crj.0000000000000058
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author Kantamaneni, Vamsi
Gurram, Krishna
Khehra, Raman
Koneru, Gopala
Kulkarni, Abhijit
author_facet Kantamaneni, Vamsi
Gurram, Krishna
Khehra, Raman
Koneru, Gopala
Kulkarni, Abhijit
author_sort Kantamaneni, Vamsi
collection PubMed
description Waldenstrom macroglobulinemia (WM) is a neoplastic disorder of the B-cell lymphoid system. A 69-year-old man with WM presented with diarrhea for 6 months. Magnetic resonance enterography showed thickening of the terminal ileum (TI). Colonosocopy with TI intubation showed a single TI ulcer, and small bowel enteroscopy revealed multiple ulcers in the TI. Biopsies from both were negative on hematoxylin and eosin staining. Immunoglobulin M immunofluorescence staining of the ulcers was positive for IgM deposits consistent with WM. After 6 cycles of chemotherapy with bendamustine and rituximab, symptoms resolved.
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spelling pubmed-66580422019-10-15 Distal Ileal Ulcers as Gastrointestinal Manifestation of Waldenstrom Macroglobulinemia Kantamaneni, Vamsi Gurram, Krishna Khehra, Raman Koneru, Gopala Kulkarni, Abhijit ACG Case Rep J Case Report Waldenstrom macroglobulinemia (WM) is a neoplastic disorder of the B-cell lymphoid system. A 69-year-old man with WM presented with diarrhea for 6 months. Magnetic resonance enterography showed thickening of the terminal ileum (TI). Colonosocopy with TI intubation showed a single TI ulcer, and small bowel enteroscopy revealed multiple ulcers in the TI. Biopsies from both were negative on hematoxylin and eosin staining. Immunoglobulin M immunofluorescence staining of the ulcers was positive for IgM deposits consistent with WM. After 6 cycles of chemotherapy with bendamustine and rituximab, symptoms resolved. Wolters Kluwer 2019-04-08 /pmc/articles/PMC6658042/ /pubmed/31616739 http://dx.doi.org/10.14309/crj.0000000000000058 Text en © 2019 The Author(s). Published by Wolters Kluwer Health, Inc. on behalf of The American College of Gastroenterology. This is an open-access article distributed under the terms of the Creative Commons Attribution-Non Commercial-No Derivatives License 4.0 (CCBY-NC-ND) (http://creativecommons.org/licenses/by-nc-nd/4.0/) , where it is permissible to download and share the work provided it is properly cited. The work cannot be changed in any way or used commercially without permission from the journal.
spellingShingle Case Report
Kantamaneni, Vamsi
Gurram, Krishna
Khehra, Raman
Koneru, Gopala
Kulkarni, Abhijit
Distal Ileal Ulcers as Gastrointestinal Manifestation of Waldenstrom Macroglobulinemia
title Distal Ileal Ulcers as Gastrointestinal Manifestation of Waldenstrom Macroglobulinemia
title_full Distal Ileal Ulcers as Gastrointestinal Manifestation of Waldenstrom Macroglobulinemia
title_fullStr Distal Ileal Ulcers as Gastrointestinal Manifestation of Waldenstrom Macroglobulinemia
title_full_unstemmed Distal Ileal Ulcers as Gastrointestinal Manifestation of Waldenstrom Macroglobulinemia
title_short Distal Ileal Ulcers as Gastrointestinal Manifestation of Waldenstrom Macroglobulinemia
title_sort distal ileal ulcers as gastrointestinal manifestation of waldenstrom macroglobulinemia
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6658042/
https://www.ncbi.nlm.nih.gov/pubmed/31616739
http://dx.doi.org/10.14309/crj.0000000000000058
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