Hepatoid Adenocarcinoma of the Rectum With Liver Metastasis in a Patient With Ulcerative Colitis

Hepatoid adenocarcinoma (HA) is a rare malignant tumor of extrahepatic origin that morphologically and immunophenotypically resembles hepatocellular carcinoma. We report a case of rectal HA with hepatic metastasis arising in a 38-year-old male with a history of ulcerative colitis. Despite elevated a...

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Autores principales: Levy, Alexander N., Ackerman, Rachel, Yilmaz, Osman, Jouhourian, Caroline, Tandon, Manish, Winter, Michael W.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Wolters Kluwer 2019
Materias:
Case Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6658070/
https://www.ncbi.nlm.nih.gov/pubmed/31616755
http://dx.doi.org/10.14309/crj.0000000000000084
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author Levy, Alexander N.
Ackerman, Rachel
Yilmaz, Osman
Jouhourian, Caroline
Tandon, Manish
Winter, Michael W.
author_facet Levy, Alexander N.
Ackerman, Rachel
Yilmaz, Osman
Jouhourian, Caroline
Tandon, Manish
Winter, Michael W.
author_sort Levy, Alexander N.
collection PubMed
description Hepatoid adenocarcinoma (HA) is a rare malignant tumor of extrahepatic origin that morphologically and immunophenotypically resembles hepatocellular carcinoma. We report a case of rectal HA with hepatic metastasis arising in a 38-year-old male with a history of ulcerative colitis. Despite elevated alpha-fetoprotein, contrast enhancement of the hepatic mass was not consistent with hepatocellular carcinoma. Immunohistochemistry revealed the diagnosis, and the patient was started on palliative chemotherapy. Colorectal HA should be considered when evaluating malignant lesions in the setting of inflammatory bowel disease and can be distinguished from other tumors based on alpha-fetoprotein, imaging, and immunostaining.
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spelling pubmed-66580702019-10-15 Hepatoid Adenocarcinoma of the Rectum With Liver Metastasis in a Patient With Ulcerative Colitis Levy, Alexander N. Ackerman, Rachel Yilmaz, Osman Jouhourian, Caroline Tandon, Manish Winter, Michael W. ACG Case Rep J Case Report Hepatoid adenocarcinoma (HA) is a rare malignant tumor of extrahepatic origin that morphologically and immunophenotypically resembles hepatocellular carcinoma. We report a case of rectal HA with hepatic metastasis arising in a 38-year-old male with a history of ulcerative colitis. Despite elevated alpha-fetoprotein, contrast enhancement of the hepatic mass was not consistent with hepatocellular carcinoma. Immunohistochemistry revealed the diagnosis, and the patient was started on palliative chemotherapy. Colorectal HA should be considered when evaluating malignant lesions in the setting of inflammatory bowel disease and can be distinguished from other tumors based on alpha-fetoprotein, imaging, and immunostaining. Wolters Kluwer 2019-05-17 /pmc/articles/PMC6658070/ /pubmed/31616755 http://dx.doi.org/10.14309/crj.0000000000000084 Text en © 2019 The Author(s). Published by Wolters Kluwer Health, Inc. on behalf of The American College of Gastroenterology. This is an open-access article distributed under the terms of the Creative Commons Attribution-Non Commercial-No Derivatives License 4.0 (CCBY-NC-ND) (http://creativecommons.org/licenses/by-nc-nd/4.0/) , where it is permissible to download and share the work provided it is properly cited. The work cannot be changed in any way or used commercially without permission from the journal.
spellingShingle Case Report
Levy, Alexander N.
Ackerman, Rachel
Yilmaz, Osman
Jouhourian, Caroline
Tandon, Manish
Winter, Michael W.
Hepatoid Adenocarcinoma of the Rectum With Liver Metastasis in a Patient With Ulcerative Colitis
title Hepatoid Adenocarcinoma of the Rectum With Liver Metastasis in a Patient With Ulcerative Colitis
title_full Hepatoid Adenocarcinoma of the Rectum With Liver Metastasis in a Patient With Ulcerative Colitis
title_fullStr Hepatoid Adenocarcinoma of the Rectum With Liver Metastasis in a Patient With Ulcerative Colitis
title_full_unstemmed Hepatoid Adenocarcinoma of the Rectum With Liver Metastasis in a Patient With Ulcerative Colitis
title_short Hepatoid Adenocarcinoma of the Rectum With Liver Metastasis in a Patient With Ulcerative Colitis
title_sort hepatoid adenocarcinoma of the rectum with liver metastasis in a patient with ulcerative colitis
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6658070/
https://www.ncbi.nlm.nih.gov/pubmed/31616755
http://dx.doi.org/10.14309/crj.0000000000000084
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