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Medication Management Models for Polymedicated Home-Dwelling Older Adults With Multiple Chronic Conditions: Protocol of a Systematic Review

BACKGROUND: Older adults with multiple chronic diseases commonly require complex medication regimes. When combined with frailty, cognitive impairment, and changing pharmacological prescriptions, older adults’ polymedication regimes increase the risk of medication-related problems (MRPs) and hospital...

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Autores principales: Pereira, Filipa, Roux, Pauline, Rosselet Amoussou, Joëlle, Martins, Maria Manuela, von Gunten, Armin, Verloo, Henk
Formato: Online Artículo Texto
Lenguaje:English
Publicado: JMIR Publications 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6658322/
https://www.ncbi.nlm.nih.gov/pubmed/31140441
http://dx.doi.org/10.2196/13582
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author Pereira, Filipa
Roux, Pauline
Rosselet Amoussou, Joëlle
Martins, Maria Manuela
von Gunten, Armin
Verloo, Henk
author_facet Pereira, Filipa
Roux, Pauline
Rosselet Amoussou, Joëlle
Martins, Maria Manuela
von Gunten, Armin
Verloo, Henk
author_sort Pereira, Filipa
collection PubMed
description BACKGROUND: Older adults with multiple chronic diseases commonly require complex medication regimes. When combined with frailty, cognitive impairment, and changing pharmacological prescriptions, older adults’ polymedication regimes increase the risk of medication-related problems (MRPs) and hospitalization. Effective, well-organized medication management could avoid MRPs and their clinical outcomes. OBJECTIVE: Identify medication management models and analyze their impact on managing and preventing MRPs for polymedicated, home-dwelling older adults. METHODS: We will conduct a systematic review of published articles in relevant professional scientific journals from inception until March 31, 2019, in the following electronic databases,: Embase; Medline OvidSP; PubMed (NOT Medline[sb]); Cumulative Index to Nursing and Allied Health Literature (CINAHL) EBSCO; PsycINFO OvidSP; Cochrane Library, Wiley; and Web of Science. We will also hand search the bibliographies of all the relevant articles found and search for unpublished studies. We will consider publications in English, French, German, Spanish, Italian, and Portuguese. Retrieved articles will be screened for eligibility. Statistical analyses will be conducted following the recommendations of the Cochrane Handbook for Systematic Reviews of Interventions, the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA), and Meta-analysis Of Observational Studies in Epidemiology (MOOSE) statements. Data will be analyzed using SPSS Statistics for Windows, version 25.0 (IBM Corp), and Review Manager, version 5.5 (The Nordic Cochrane Centre, The Cochrane Collaboration). RESULTS: A preliminary search in Embase delivered 3272 references. This preliminary search allows us to complete our research strategy with equation development and to search the other databases. Relevant articles identified will allow for searching the reference lists for unpublished studies. The inclusion and exclusion criteria will be rigorously respected in the study selection. The entire study is expected to be completed by January 2020. CONCLUSIONS: This review will provide an exhaustive view of medication management models that could be effective for polymedicated, home-dwelling older adults and will allow us to analyze their impact on managing and preventing MRPs. TRIAL REGISTRATION: PROSPERO CRD42018117287; https://www.crd.york.ac.uk/prospero/display_record.php?RecordID=117287 (Archived by WebCite at http://www.webcitation.org/77fCfbCjT) INTERNATIONAL REGISTERED REPORT IDENTIFIER (IRRID): DERR1-10.2196/13582
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spelling pubmed-66583222019-08-08 Medication Management Models for Polymedicated Home-Dwelling Older Adults With Multiple Chronic Conditions: Protocol of a Systematic Review Pereira, Filipa Roux, Pauline Rosselet Amoussou, Joëlle Martins, Maria Manuela von Gunten, Armin Verloo, Henk JMIR Res Protoc Protocol BACKGROUND: Older adults with multiple chronic diseases commonly require complex medication regimes. When combined with frailty, cognitive impairment, and changing pharmacological prescriptions, older adults’ polymedication regimes increase the risk of medication-related problems (MRPs) and hospitalization. Effective, well-organized medication management could avoid MRPs and their clinical outcomes. OBJECTIVE: Identify medication management models and analyze their impact on managing and preventing MRPs for polymedicated, home-dwelling older adults. METHODS: We will conduct a systematic review of published articles in relevant professional scientific journals from inception until March 31, 2019, in the following electronic databases,: Embase; Medline OvidSP; PubMed (NOT Medline[sb]); Cumulative Index to Nursing and Allied Health Literature (CINAHL) EBSCO; PsycINFO OvidSP; Cochrane Library, Wiley; and Web of Science. We will also hand search the bibliographies of all the relevant articles found and search for unpublished studies. We will consider publications in English, French, German, Spanish, Italian, and Portuguese. Retrieved articles will be screened for eligibility. Statistical analyses will be conducted following the recommendations of the Cochrane Handbook for Systematic Reviews of Interventions, the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA), and Meta-analysis Of Observational Studies in Epidemiology (MOOSE) statements. Data will be analyzed using SPSS Statistics for Windows, version 25.0 (IBM Corp), and Review Manager, version 5.5 (The Nordic Cochrane Centre, The Cochrane Collaboration). RESULTS: A preliminary search in Embase delivered 3272 references. This preliminary search allows us to complete our research strategy with equation development and to search the other databases. Relevant articles identified will allow for searching the reference lists for unpublished studies. The inclusion and exclusion criteria will be rigorously respected in the study selection. The entire study is expected to be completed by January 2020. CONCLUSIONS: This review will provide an exhaustive view of medication management models that could be effective for polymedicated, home-dwelling older adults and will allow us to analyze their impact on managing and preventing MRPs. TRIAL REGISTRATION: PROSPERO CRD42018117287; https://www.crd.york.ac.uk/prospero/display_record.php?RecordID=117287 (Archived by WebCite at http://www.webcitation.org/77fCfbCjT) INTERNATIONAL REGISTERED REPORT IDENTIFIER (IRRID): DERR1-10.2196/13582 JMIR Publications 2019-05-28 /pmc/articles/PMC6658322/ /pubmed/31140441 http://dx.doi.org/10.2196/13582 Text en ©Filipa Pereira, Pauline Roux, Joëlle Rosselet Amoussou, Maria Manuela Martins, Armin von Gunten, Henk Verloo. Originally published in JMIR Research Protocols (http://www.researchprotocols.org), 28.05.2019. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work, first published in JMIR Research Protocols, is properly cited. The complete bibliographic information, a link to the original publication on http://www.researchprotocols.org, as well as this copyright and license information must be included.
spellingShingle Protocol
Pereira, Filipa
Roux, Pauline
Rosselet Amoussou, Joëlle
Martins, Maria Manuela
von Gunten, Armin
Verloo, Henk
Medication Management Models for Polymedicated Home-Dwelling Older Adults With Multiple Chronic Conditions: Protocol of a Systematic Review
title Medication Management Models for Polymedicated Home-Dwelling Older Adults With Multiple Chronic Conditions: Protocol of a Systematic Review
title_full Medication Management Models for Polymedicated Home-Dwelling Older Adults With Multiple Chronic Conditions: Protocol of a Systematic Review
title_fullStr Medication Management Models for Polymedicated Home-Dwelling Older Adults With Multiple Chronic Conditions: Protocol of a Systematic Review
title_full_unstemmed Medication Management Models for Polymedicated Home-Dwelling Older Adults With Multiple Chronic Conditions: Protocol of a Systematic Review
title_short Medication Management Models for Polymedicated Home-Dwelling Older Adults With Multiple Chronic Conditions: Protocol of a Systematic Review
title_sort medication management models for polymedicated home-dwelling older adults with multiple chronic conditions: protocol of a systematic review
topic Protocol
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6658322/
https://www.ncbi.nlm.nih.gov/pubmed/31140441
http://dx.doi.org/10.2196/13582
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