Broken heart: A matter of the endoplasmic reticulum stress bad management?

Cardiovascular diseases are the number one cause of morbidity and mortality in the United States and worldwide. The induction of the endoplasmic reticulum (ER) stress, a result of a disruption in the ER homeostasis, was found to be highly associated with cardiovascular diseases such as hypertension,...

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Detalles Bibliográficos
Autores principales: Belmadani, Souad, Matrougui, Khalid
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Baishideng Publishing Group Inc 2019
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6658386/
https://www.ncbi.nlm.nih.gov/pubmed/31367278
http://dx.doi.org/10.4330/wjc.v11.i6.159
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author Belmadani, Souad
Matrougui, Khalid
author_facet Belmadani, Souad
Matrougui, Khalid
author_sort Belmadani, Souad
collection PubMed
description Cardiovascular diseases are the number one cause of morbidity and mortality in the United States and worldwide. The induction of the endoplasmic reticulum (ER) stress, a result of a disruption in the ER homeostasis, was found to be highly associated with cardiovascular diseases such as hypertension, diabetes, ischemic heart diseases and heart failure. This review will discuss the latest literature on the different aspects of the involvement of the ER stress in cardiovascular complications and the potential of targeting the ER stress pathways as a new therapeutic approach for cardiovascular complications.
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spelling pubmed-66583862019-07-31 Broken heart: A matter of the endoplasmic reticulum stress bad management? Belmadani, Souad Matrougui, Khalid World J Cardiol Review Cardiovascular diseases are the number one cause of morbidity and mortality in the United States and worldwide. The induction of the endoplasmic reticulum (ER) stress, a result of a disruption in the ER homeostasis, was found to be highly associated with cardiovascular diseases such as hypertension, diabetes, ischemic heart diseases and heart failure. This review will discuss the latest literature on the different aspects of the involvement of the ER stress in cardiovascular complications and the potential of targeting the ER stress pathways as a new therapeutic approach for cardiovascular complications. Baishideng Publishing Group Inc 2019-06-26 2019-06-26 /pmc/articles/PMC6658386/ /pubmed/31367278 http://dx.doi.org/10.4330/wjc.v11.i6.159 Text en ©The Author(s) 2019. Published by Baishideng Publishing Group Inc. All rights reserved. http://creativecommons.org/licenses/by-nc/4.0/ This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial.
spellingShingle Review
Belmadani, Souad
Matrougui, Khalid
Broken heart: A matter of the endoplasmic reticulum stress bad management?
title Broken heart: A matter of the endoplasmic reticulum stress bad management?
title_full Broken heart: A matter of the endoplasmic reticulum stress bad management?
title_fullStr Broken heart: A matter of the endoplasmic reticulum stress bad management?
title_full_unstemmed Broken heart: A matter of the endoplasmic reticulum stress bad management?
title_short Broken heart: A matter of the endoplasmic reticulum stress bad management?
title_sort broken heart: a matter of the endoplasmic reticulum stress bad management?
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6658386/
https://www.ncbi.nlm.nih.gov/pubmed/31367278
http://dx.doi.org/10.4330/wjc.v11.i6.159
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