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Analysis of polygenic risk score usage and performance in diverse human populations

A historical tendency to use European ancestry samples hinders medical genetics research, including the use of polygenic scores, which are individual-level metrics of genetic risk. We analyze the first decade of polygenic scoring studies (2008–2017, inclusive), and find that 67% of studies included...

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Detalles Bibliográficos
Autores principales:	Duncan, L., Shen, H., Gelaye, B., Meijsen, J., Ressler, K., Feldman, M., Peterson, R., Domingue, B.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2019
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6658471/ https://www.ncbi.nlm.nih.gov/pubmed/31346163 http://dx.doi.org/10.1038/s41467-019-11112-0

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