Lateral dispersion is required for circuit integration of newly generated dentate granule cells

The process of circuit integration of newly-generated dentate granule cells of the hippocampus has been presumed to be a dynamic process. In fact, little is known regarding the initial development of newly generated neurons prior to circuit integration and the significance of this stage for circuit...

Descripción completa

Detalles Bibliográficos
Autores principales: Wang, Jia, Shen, Jia, Kirschen, Gregory W., Gu, Yan, Jessberger, Sebastian, Ge, Shaoyu
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6658520/
https://www.ncbi.nlm.nih.gov/pubmed/31346164
http://dx.doi.org/10.1038/s41467-019-11206-9
_version_ 1783438972375007232
author Wang, Jia
Shen, Jia
Kirschen, Gregory W.
Gu, Yan
Jessberger, Sebastian
Ge, Shaoyu
author_facet Wang, Jia
Shen, Jia
Kirschen, Gregory W.
Gu, Yan
Jessberger, Sebastian
Ge, Shaoyu
author_sort Wang, Jia
collection PubMed
description The process of circuit integration of newly-generated dentate granule cells of the hippocampus has been presumed to be a dynamic process. In fact, little is known regarding the initial development of newly generated neurons prior to circuit integration and the significance of this stage for circuit integration. Here, using advanced live imaging methods, we systematically analyze the dynamic dispersion of newly generated neurons in the neurogenic zone and observe that cells that are physically adjacent coordinate their lateral dispersion. Whole-cell recordings of adjacent newly generated neurons reveal that they are coupled via gap junctions. The dispersion of newly generated cells in the neurogenic zone is restricted when this coupling is disrupted, which severely impairs their subsequent integration into the hippocampal circuit. The results of this study reveal that the dynamic dispersion of newly generated dentate granule cells in the neurogenic zone is a required developmental stage for circuit integration.
format Online
Article
Text
id pubmed-6658520
institution National Center for Biotechnology Information
language English
publishDate 2019
publisher Nature Publishing Group UK
record_format MEDLINE/PubMed
spelling pubmed-66585202019-07-29 Lateral dispersion is required for circuit integration of newly generated dentate granule cells Wang, Jia Shen, Jia Kirschen, Gregory W. Gu, Yan Jessberger, Sebastian Ge, Shaoyu Nat Commun Article The process of circuit integration of newly-generated dentate granule cells of the hippocampus has been presumed to be a dynamic process. In fact, little is known regarding the initial development of newly generated neurons prior to circuit integration and the significance of this stage for circuit integration. Here, using advanced live imaging methods, we systematically analyze the dynamic dispersion of newly generated neurons in the neurogenic zone and observe that cells that are physically adjacent coordinate their lateral dispersion. Whole-cell recordings of adjacent newly generated neurons reveal that they are coupled via gap junctions. The dispersion of newly generated cells in the neurogenic zone is restricted when this coupling is disrupted, which severely impairs their subsequent integration into the hippocampal circuit. The results of this study reveal that the dynamic dispersion of newly generated dentate granule cells in the neurogenic zone is a required developmental stage for circuit integration. Nature Publishing Group UK 2019-07-25 /pmc/articles/PMC6658520/ /pubmed/31346164 http://dx.doi.org/10.1038/s41467-019-11206-9 Text en © The Author(s) 2019 Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.
spellingShingle Article
Wang, Jia
Shen, Jia
Kirschen, Gregory W.
Gu, Yan
Jessberger, Sebastian
Ge, Shaoyu
Lateral dispersion is required for circuit integration of newly generated dentate granule cells
title Lateral dispersion is required for circuit integration of newly generated dentate granule cells
title_full Lateral dispersion is required for circuit integration of newly generated dentate granule cells
title_fullStr Lateral dispersion is required for circuit integration of newly generated dentate granule cells
title_full_unstemmed Lateral dispersion is required for circuit integration of newly generated dentate granule cells
title_short Lateral dispersion is required for circuit integration of newly generated dentate granule cells
title_sort lateral dispersion is required for circuit integration of newly generated dentate granule cells
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6658520/
https://www.ncbi.nlm.nih.gov/pubmed/31346164
http://dx.doi.org/10.1038/s41467-019-11206-9
work_keys_str_mv AT wangjia lateraldispersionisrequiredforcircuitintegrationofnewlygenerateddentategranulecells
AT shenjia lateraldispersionisrequiredforcircuitintegrationofnewlygenerateddentategranulecells
AT kirschengregoryw lateraldispersionisrequiredforcircuitintegrationofnewlygenerateddentategranulecells
AT guyan lateraldispersionisrequiredforcircuitintegrationofnewlygenerateddentategranulecells
AT jessbergersebastian lateraldispersionisrequiredforcircuitintegrationofnewlygenerateddentategranulecells
AT geshaoyu lateraldispersionisrequiredforcircuitintegrationofnewlygenerateddentategranulecells

Ejemplares similares