Lysosomal degradation of newly formed insulin granules contributes to β cell failure in diabetes

Compromised function of insulin-secreting pancreatic β cells is central to the development and progression of Type 2 Diabetes (T2D). However, the mechanisms underlying β cell failure remain incompletely understood. Here, we report that metabolic stress markedly enhances macroautophagy-independent ly...

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Detalles Bibliográficos
Autores principales: Pasquier, Adrien, Vivot, Kevin, Erbs, Eric, Spiegelhalter, Coralie, Zhang, Zhirong, Aubert, Victor, Liu, Zengzhen, Senkara, Meryem, Maillard, Elisa, Pinget, Michel, Kerr-Conte, Julie, Pattou, François, Marciniak, Gilbert, Ganzhorn, Axel, Ronchi, Paolo, Schieber, Nicole L., Schwab, Yannick, Saftig, Paul, Goginashvili, Alexander, Ricci, Romeo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6658524/
https://www.ncbi.nlm.nih.gov/pubmed/31346174
http://dx.doi.org/10.1038/s41467-019-11170-4

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