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Neuronal XBP-1 Activates Intestinal Lysosomes to Improve Proteostasis in C. elegans
The unfolded protein response of the endoplasmic reticulum (UPR(ER)) is a crucial mediator of secretory pathway homeostasis. Expression of the spliced and active form of the UPR(ER) transcription factor XBP-1, XBP-1s, in the nervous system triggers activation of the UPR(ER) in the intestine of Caeno...
| Autores principales: | , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Cell Press
2019
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6658570/ https://www.ncbi.nlm.nih.gov/pubmed/31303493 http://dx.doi.org/10.1016/j.cub.2019.06.031 |