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Bedaquiline Eliminates Bactericidal Activity of β-Lactams against Mycobacterium abscessus

The β-lactams imipenem and cefoxitin are used for the treatment of Mycobacterium abscessus lung infections. Here, we show that these cell wall synthesis inhibitors trigger a lethal bacterial ATP burst by increasing oxidative phosphorylation. Cotreatment of M. abscessus with the antimycobacterial ATP...

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Detalles Bibliográficos
Autores principales:	Lindman, Marissa, Dick, Thomas
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Society for Microbiology 2019
Materias:	Mechanisms of Action: Physiological Effects
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6658768/ https://www.ncbi.nlm.nih.gov/pubmed/31182531 http://dx.doi.org/10.1128/AAC.00827-19

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